(Des-Gly10,Pro-NHEt9)-LHRH acetate salt

Modify Date: 2024-01-02 18:28:35

(Des-Gly10,Pro-NHEt9)-LHRH acetate salt Structure
(Des-Gly10,Pro-NHEt9)-LHRH acetate salt structure
Common Name (Des-Gly10,Pro-NHEt9)-LHRH acetate salt
CAS Number 38234-21-8 Molecular Weight 1153.292
Density 1.5±0.1 g/cm3 Boiling Point N/A
Molecular Formula C55H76N16O12 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of (Des-Gly10,Pro-NHEt9)-LHRH acetate salt


Fertirelin is a GnRH and LH-RH analogue; it also becomes the treatment choice for reversing cow follicular cysts.

 Names

Name fertirelin
Synonym More Synonyms

 (Des-Gly10,Pro-NHEt9)-LHRH acetate salt Biological Activity

Description Fertirelin is a GnRH and LH-RH analogue; it also becomes the treatment choice for reversing cow follicular cysts.
Related Catalog
In Vivo Fertirelin, an analog of GnRH 2.5 to 10 times more potent than native GnRH , has become the treatment of choice for reversing follicular cysts[1]. Administration of high doses of Fertirelin is found to reduce superovulatory responses[2].
Animal Admin Mice[2] Nulliparious female mice weighed 25-28 g (8-9 weeks) are used throughout the study. The mice are ddY strain and specific pathohen-free. As ovulation can be induced in mice at any time with administration of human chorionic gonadotrophin (hCG), 5.0 IU of hCG is injected subcutaneously into each mouse at 17:00, irrespective of the stage of the estrus cycle. This day is designated as Day 0. Nine groups are established according to the dose of Fertirelin ranging from 0.001 to 1.0 μg, and the administration are carried out at 22:00 on Day 0 and at 2:00, 6:00, 10:00 and 14:00 on Day 1[2].
References

[1]. Nakao T et al. Effect of fenprostalene 14 days after fertirelin treatment on intervals from treatment to conception in cows with follicular cysts diagnosed by milk progesterone test. J Vet Med Sci. 1993 Apr;55(2):207-10.

[2]. Nariai K, et al. Optimum dose of LH-RH analogue Fertirelin Acetate for the induction of superovulation in mice. Exp Anim. 2005 Jan;54(1):97-9.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Molecular Formula C55H76N16O12
Molecular Weight 1153.292
Exact Mass 1152.582886
PSA 429.04000
LogP -1.35
Index of Refraction 1.698
Storage condition -15°C

 Safety Information

Hazard Codes T
Risk Phrases 60
Safety Phrases 53-22-36/37/39-45

 Synonyms

UNII:Q041AO6T91
Fertireline [inn-french]
[DES-GLY10] LH-RH,ETHYL AMIDE
fertirelin
Fertirelin [inn:ban]
Fertirelina [inn-spanish]
pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-NHEt
5-oxo-Pro-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-NHEt
L-Prolinamide, 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycyl-L-leucyl-L-arginyl-N-ethyl-
Fertireline
pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-NH-CH2-CH3
(DES-GLY10,PRO-NHET9)-LHRH
5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide
Fertirelina
Fertirelin Acetate
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