NPD926
Modify Date: 2024-09-16 20:02:52
NPD926 structure
|
Common Name | NPD926 | ||
|---|---|---|---|---|
| CAS Number | 384361-79-9 | Molecular Weight | 479.053 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 631.8±55.0 °C at 760 mmHg | |
| Molecular Formula | C29H35ClN2O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 335.9±31.5 °C | |
Use of NPD926A small molecule ROS inducer that induces rapid cell death in cancer cells, induces reactive oxygen species via cellular glutathione depletion; preferentially induces effects in KRAS-transformed fibroblast cells, compared with their untransformed counterparts, sensitizes cells to inhibitors of system x(c)⁻, a cystine-glutamate antiporter considered to be a potential therapeutic target in cancers including cancer stem cells. |
| Name | 2-Chloro-N-[4-(dimethylamino)benzyl]-N-[3-(4-isopropoxyphenyl)-3-phenylpropyl]acetamide |
|---|---|
| Synonym | More Synonyms |
| Description | A small molecule ROS inducer that induces rapid cell death in cancer cells, induces reactive oxygen species via cellular glutathione depletion; preferentially induces effects in KRAS-transformed fibroblast cells, compared with their untransformed counterparts, sensitizes cells to inhibitors of system x(c)⁻, a cystine-glutamate antiporter considered to be a potential therapeutic target in cancers including cancer stem cells. |
|---|---|
| References | References 1. Kawamura T, et al. Biochem J. 2014 Oct 1;463(1):53-63. View Related Products by Target Other Targets |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 631.8±55.0 °C at 760 mmHg |
| Molecular Formula | C29H35ClN2O2 |
| Molecular Weight | 479.053 |
| Flash Point | 335.9±31.5 °C |
| Exact Mass | 478.238708 |
| LogP | 6.35 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.585 |
| 2-Chloro-N-[4-(dimethylamino)benzyl]-N-[3-(4-isopropoxyphenyl)-3-phenylpropyl]acetamide |
| Acetamide, 2-chloro-N-[[4-(dimethylamino)phenyl]methyl]-N-[3-[4-(1-methylethoxy)phenyl]-3-phenylpropyl]- |