SNAP-7941

Modify Date: 2024-01-10 10:51:14

SNAP-7941 Structure
SNAP-7941 structure
Common Name SNAP-7941
CAS Number 387825-78-7 Molecular Weight 613.652
Density 1.3±0.1 g/cm3 Boiling Point N/A
Molecular Formula C33H41F2N5O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of SNAP-7941


SNAP-7941 is a selective, high-affinity, and competitive MCH1 receptor (MCH1-R) antagonist with Ki of 15 nM; inhibits food intake stimulated by central administration of MCH, reduces consumption of palatable food, decreases in body weight in rats with diet-induced obesity; also produces effects similar to clinically used antidepressants and anxiolytics in animal models of depression/anxiety. Obesity Discontinued

 Names

Name SNAP-7941
Synonym More Synonyms

 SNAP-7941 Biological Activity

Description SNAP-7941 is a selective, high-affinity, and competitive MCH1 receptor (MCH1-R) antagonist with Ki of 15 nM; inhibits food intake stimulated by central administration of MCH, reduces consumption of palatable food, decreases in body weight in rats with diet-induced obesity; also produces effects similar to clinically used antidepressants and anxiolytics in animal models of depression/anxiety. Obesity Discontinued
References References 1. Borowsky B, et al. Nat Med. 2002 Aug;8(8):825-30. 2. Basso AM, et al. Eur J Pharmacol. 2006 Jul 1;540(1-3):115-20. 3. Millan MJ, et al. Int J Neuropsychopharmacol. 2008 Dec;11(8):1105-22. View Related Products by Target Melanin-concentrating Hormone Receptor (MCHR) Obesity

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Molecular Formula C33H41F2N5O6
Molecular Weight 613.652
Exact Mass 613.271179
LogP 2.47
Index of Refraction 1.572

 Synonyms

Methyl (4S)-3-({3-[4-(3-acetamidophenyl)-1-piperidinyl]propyl}carbamoyl)-4-(3,4-difluorophenyl)-6-(methoxymethyl)-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate
SNAP-7941
5-Pyrimidinecarboxylic acid, 1-[[[3-[4-[3-(acetylamino)phenyl]-1-piperidinyl]propyl]amino]carbonyl]-6-(3,4-difluorophenyl)-1,2,3,6-tetrahydro-4-(methoxymethyl)-2-oxo-, methyl ester, (6S)-
methyl (4S)-3-[(3-{4-[3-(acetylamino)phenyl]piperidin-1-yl}propyl)carbamoyl]-4-(3,4-difluorophenyl)-6-(methoxymethyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
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