Prasugrel hydrochloride

Modify Date: 2024-01-02 20:43:15

Prasugrel hydrochloride Structure
Prasugrel hydrochloride structure
Common Name Prasugrel hydrochloride
CAS Number 389574-19-0 Molecular Weight 409.902
Density N/A Boiling Point 493.5ºC at 760 mmHg
Molecular Formula C20H21ClFNO3S Melting Point N/A
MSDS N/A Flash Point 252.3℃

 Use of Prasugrel hydrochloride


Prasugrel hydrochloride is a platelet inhibitor with IC50 value of 1.8 μM.Target: P2Y12 receptorPrasugrel hydrochloride is a novel platelet inhibitor used for the reduction of thrombotic cardiovascular events (including stent thrombosis) in patients with acute coronary syndrome who are to be managed with PCI [2].Prasugrel hydrochloride reduces the aggregation ("clumping") of platelets by irreversibly binding to P2Y12 receptors. In rat platelets, prasugrel hydrochloride AM inhibited in vitro platelet aggregation induced by ADP (10 μm) with an IC50 value of 1.8 Μm [2]. Clinical indications: Acute coronary syndrome; Ischemic heart disease; Sickle cell anemia; Stroke; Vascular occlusive diseaseFDA Approved Date: February 2009Toxicity: Hypertension; Headache; Hypercholesterolemia/hyperlipidemia; Nausea; Epistaxis

 Names

Name [5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-6,7-dihydro-4H-thieno[3,2-c]pyridin-2-yl] acetate,hydrochloride
Synonym More Synonyms

 Prasugrel hydrochloride Biological Activity

Description Prasugrel hydrochloride is a platelet inhibitor with IC50 value of 1.8 μM.Target: P2Y12 receptorPrasugrel hydrochloride is a novel platelet inhibitor used for the reduction of thrombotic cardiovascular events (including stent thrombosis) in patients with acute coronary syndrome who are to be managed with PCI [2].Prasugrel hydrochloride reduces the aggregation ("clumping") of platelets by irreversibly binding to P2Y12 receptors. In rat platelets, prasugrel hydrochloride AM inhibited in vitro platelet aggregation induced by ADP (10 μm) with an IC50 value of 1.8 Μm [2]. Clinical indications: Acute coronary syndrome; Ischemic heart disease; Sickle cell anemia; Stroke; Vascular occlusive diseaseFDA Approved Date: February 2009Toxicity: Hypertension; Headache; Hypercholesterolemia/hyperlipidemia; Nausea; Epistaxis
Related Catalog
References

[1]. Sugidachi A, et al. The greater in vivo antiplatelet effects of prasugrel as compared to clopidogrel reflect more efficient generation of its active metabolite with similar antiplatelet activity to that of clopidogrel's active metabolite. J Thromb Haemost. 2007 Jul;5(7):1545-51. Epub 2007 Apr 19.

[2]. Baker WL, et al. Role of prasugrel, a novel P2Y(12) receptor antagonist, in the management of acute coronary syndromes. Am J Cardiovasc Drugs. 2009;9(4):213-29.

 Chemical & Physical Properties

Boiling Point 493.5ºC at 760 mmHg
Molecular Formula C20H21ClFNO3S
Molecular Weight 409.902
Flash Point 252.3℃
Exact Mass 409.091461
PSA 74.85000
LogP 4.63090
Storage condition -20℃

 Synonyms

5-[2-Cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate hydrochloride (1:1)
Prasugrel hydrochloride
Ethanone, 2-[2-(acetyloxy)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl]-1-cyclopropyl-2-(2-fluorophenyl)-, hydrochloride (1:1)
Prasugrel0 Hydrochloriden(Discontinued)
Prasugren hydrochloride
Prasugrelhydrochloride
Efient
Prasugrel (hydrochloride)
Top Suppliers:I want be here





Get all suppliers and price by the below link:

Prasugrel hydrochloride suppliers


Price: $240/100mg

Reference only. check more Prasugrel hydrochloride price