Promestriene

Modify Date: 2024-01-08 15:15:26

Promestriene Structure
Promestriene structure
 Common Name Promestriene
CAS Number 39219-28-8 Molecular Weight 328.488
Density 1.1±0.1 g/cm3 Boiling Point 436.8±45.0 °C at 760 mmHg
Molecular Formula C22H32O2 Melting Point 64-660ºC
MSDS N/A Flash Point 153.3±28.3 °C

 Use of Promestriene


Promestriene is a synthetic diethyl-ether of estradiol and a locally effective estrogen. Promestriene has an efficient action on vaginal atrophy while it is minimally absorbed[1][2].

 Names

Name Promestriene
Synonym More Synonyms

 Promestriene Biological Activity

Description Promestriene is a synthetic diethyl-ether of estradiol and a locally effective estrogen. Promestriene has an efficient action on vaginal atrophy while it is minimally absorbed[1][2].
Related Catalog
In Vitro Promestriene is an analogue of oestradiol which is minimally absorbed and devoid of systemic effects when administered intravaginally, either as gynecological cream or capsules[2]. Topical Promestriene is minimally absorbed with chronic use and has been reported to significantly improve the symptoms of vaginal atrophy[3].
References

[1]. Isabel Santos, et al. Urogenital Disorders Associated With Oestrogen Deficiency: The Role of Promestriene as Topical Oestrogen Therapy. Gynecol Endocrinol. 2010 Sep;26(9):644-51.

[2]. Lino Del Pup, et al. Promestriene, a Specific Topic Estrogen. Review of 40 Years of Vaginal Atrophy Treatment: Is It Safe Even in Cancer Patients. Anticancer Drugs. 2013 Nov;24(10):989-98.

[3]. AJO Almodovar, et al. Abstract P5-05-07: Promestriene effects on estrogen-sensitive breast cancer cell proliferation in vitro. Cancer Res 2013;73(24 Suppl): Abstract nr P5-05-07.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 436.8±45.0 °C at 760 mmHg
Melting Point 64-660ºC
Molecular Formula C22H32O2
Molecular Weight 328.488
Flash Point 153.3±28.3 °C
Exact Mass 328.240234
PSA 18.46000
LogP 6.48
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.546
Storage condition -20°C Freezer

 Synonyms

17-Methoxy-3-propoxyestra-1,3,5(10)-triene
MFCD00867247
Promestriene
EINECS 254-361-6
Promestriene [DCF:INN]
Estra-1,3,5(10)-triene, 17-methoxy-3-propoxy-
3-Propoxy-17beta-methoxy-1,3,5(10)-estratriene
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