kievitone

Modify Date: 2024-01-06 21:18:54

kievitone Structure
kievitone structure
Common Name kievitone
CAS Number 40105-60-0 Molecular Weight 356.36900
Density 1.384g/cm3 Boiling Point 639.6ºC at 760 mmHg
Molecular Formula C20H20O6 Melting Point N/A
MSDS N/A Flash Point 231.4ºC

 Use of kievitone


Kievitone, an isoflavanone, could be isolated from hypocotyls of Phaseolus vulgaris L. infected with Rhizoctonia solani Kühn. Kievitone has antifungal activity and antitumor activity[1][2].

 Names

Name kievitone
Synonym More Synonyms

 kievitone Biological Activity

Description Kievitone, an isoflavanone, could be isolated from hypocotyls of Phaseolus vulgaris L. infected with Rhizoctonia solani Kühn. Kievitone has antifungal activity and antitumor activity[1][2].
Related Catalog
In Vitro Kievitone (0-40 μM; 4 天) 抑制雌激素受体 (ER) 阳性乳腺癌细胞株 MCF-7 和 T47D 以及 ER 阴性乳腺癌细胞株 SKBR3 的增殖 (IC50 值 为 5-18 μM)[2]。 Kievitone (0-40 μM; 48 h) 抑制由胰岛素样生长因子 1、胰岛素样生长因子 2、碱性成纤维细胞生长因子或转化生长因子 α 刺激的 MCF-7 细胞的 DNA 合成[2]。 Cell Viability Assay[2] Cell Line: MCF-7, T47D and SKBR3 cells Concentration: 0-40 μM Incubation Time: 4 days Result: Inhibited breast cancer cell proliferation in a dose-dependent manner.
References

[1]. Smith DA, et, al. Kievitone: the principal antifungal component of “substance II” isolated from Rhizoctonia-infected bean tissues. 1973 Apr;3(14):179-84.

[2]. Hoffman R. Potent inhibition of breast cancer cell lines by the isoflavonoid kievitone: comparison with genistein. Biochem Biophys Res Commun. 1995 Jun 15;211(2):600-6.  

 Chemical & Physical Properties

Density 1.384g/cm3
Boiling Point 639.6ºC at 760 mmHg
Molecular Formula C20H20O6
Molecular Weight 356.36900
Flash Point 231.4ºC
Exact Mass 356.12600
PSA 107.22000
LogP 3.37660
Index of Refraction 1.663

 Synonyms

3-(2,4-dihydroxyphenyl)-5,7-dihydroxy-8-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one
3-(2,4-dihydroxyphenyl)-5,7-dihydroxy-8-(3-methylbut-2-en-1-yl)-2,3-dihydro-4H-chromen-4-one
Kievitone