5-Methyl-1H-pyrazole-3-carboxylic acid

Modify Date: 2024-01-02 19:19:34

5-Methyl-1H-pyrazole-3-carboxylic acid structure	Common Name	5-Methyl-1H-pyrazole-3-carboxylic acid
	CAS Number	402-61-9	Molecular Weight	126.11
	Density	1.404g/cm3	Boiling Point	388.8ºC at 760mmHg
	Molecular Formula	C₅H₆N₂O₂	Melting Point	241 °C
	MSDS	Chinese USA	Flash Point	188.9ºC

Use of 5-Methyl-1H-pyrazole-3-carboxylic acid

AS057278 is a potent, selective, orally active and blood-brain barrier (BBB) penetrant non-peptidic D-amino acid oxidase (DAAO) inhibitor with an IC50 value of 0.91 μM and EC50 of 2.2-3.95 μM. AS057278 can normalize phencyclidine (PCP)-induced prepulse inhibition in mice. AS057278 can be used for researching schizophrenia[1].

Name	5-methyl-pyrazole-3-carboxylic acid
Synonym	More Synonyms

Description	AS057278 is a potent, selective, orally active and blood-brain barrier (BBB) penetrant non-peptidic D-amino acid oxidase (DAAO) inhibitor with an IC50 value of 0.91 μM and EC50 of 2.2-3.95 μM. AS057278 can normalize phencyclidine (PCP)-induced prepulse inhibition in mice. AS057278 can be used for researching schizophrenia[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
Target	IC50: 0.91 μM (DAAO)[1]
In Vivo	AS057278 (PO; 20 mg/kg b.i.d for 28 days; 80 mg/kg single dosage) normalizes phencyclidine (PCP)-induced prepulse inhibition[1]. AS057278 (10 mg/kg; PO and IV; single dosage) exhibits good pharmacokinetic effects[1]. Pharmacokinetic Parameters of AS057278 in male Sprague-Dawley rats[1]. IV (10 mg/kg) PO (10 mg/kg) C0 (ng/mL) 100,557.3 Cmax (ng/mL) 73,559.8 8088.8 tmax (h) 0.083 1 CZ (ng/mL) 26.8 40.5 tZ (h) 24 24 AUCZ (ng/mL·h) 45,596.2 18,254.4 λZ (h^-1) 0.124 0.096 AUC (ng/mL·h) 45,810.9 18,649.9 VZ (L/kg) 1.76 VSS (L/kg) 0.24 CL (L/kg/h) 0.22 MRT (h) 1.087 F 0.407 Animal Model: Males C57BL/6J mice[1] Dosage: 80 mg/kg, 20 mg/kg Administration: PO; 20 mg/kg b.i.d for 28 days; 80 mg/kg single dosage Result: Normalized phencyclidine (PCP)-induced prepulse inhibition after acute (80 mg/kg) and chronic (20 mg/kg b.i.d.) oral administration in mice. Animal Model: Male Sprague-Dawley rats[1] Dosage: 10 mg/kg Administration: PO and IV; single dosage (Pharmacokinetics Analysis) Result: Exhibited good pharmacokinetic effect.
References	[1]. Adage T, et al. In vitro and in vivo pharmacological profile of AS057278, a selective d-amino acid oxidase inhibitor with potential anti-psychotic properties. Eur Neuropsychopharmacol. 2008;18(3):200-214.

Density	1.404g/cm3
Boiling Point	388.8ºC at 760mmHg
Melting Point	241 °C
Molecular Formula	C₅H₆N₂O₂
Molecular Weight	126.11
Flash Point	188.9ºC
Exact Mass	126.04300
PSA	65.98000
LogP	0.41630
Index of Refraction	1.595
Storage condition	2~8°C

5-Methyl-1H-pyrazole-3-carboxylic acid MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ6407500

CHEMICAL NAME :: Pyrazole-3-carboxylic acid, 5-methyl-

CAS REGISTRY NUMBER :: 402-61-9

BEILSTEIN REFERENCE NO. :: 0002906

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C5-H6-N2-O2

MOLECULAR WEIGHT :: 126.13

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 27,295,1964

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S37/39
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	UQ6407500
HS Code	2933199090

Precursor 9
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DownStream 10
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HS Code	2933199090
Summary	2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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We have found that mutation of D-amino acid oxidase (DAO) diminished formalin-induced tonic pain. The present research further studied the analgesic effects of a series of DAO inhibitors in this model...

In vitro and in vivo pharmacological profile of AS057278, a selective d-amino acid oxidase inhibitor with potential anti-psychotic properties.

Eur. Neuropsychopharmacol. 18(3) , 200-14, (2008)

Non-competitive N-methyl-d-aspartate (NMDA) blockers induce schizophrenic-like behavior in healthy volunteers and exacerbate symptomatology in schizophrenic patients. Hence, a compound able to enhance...

5-Methyl-1H-pyrazole-3-carboxylic acid

MFCD00462235

3-Methyl-1H-pyrazole-5-carboxylic acid

AS057278 5-Methylpyrazole-3-carboxylic acid MPC