DSP-4
DSP-4 structure
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Common Name | DSP-4 | ||
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| CAS Number | 40616-75-9 | Molecular Weight | 313.06100 | |
| Density | 1.338g/cm3 | Boiling Point | 276.7ºC at 760 mmHg | |
| Molecular Formula | C11H16BrCl2N | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
Use of DSP-4DSP-4 hydrochloride (Neurotoxin DSP 4 hydrochloride) is a highly selective neurotoxin and readily passes the blood-brain barrier with neurotoxic effects on noradrenergic neurons of adult and developing rats, can be used for the temporary selective degradation of the central and peripheral noradrenergic neurons, mainly those from the locus coeruleus (LC)[1][2]. |
| Name | N-(2-Chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | DSP-4 hydrochloride (Neurotoxin DSP 4 hydrochloride) is a highly selective neurotoxin and readily passes the blood-brain barrier with neurotoxic effects on noradrenergic neurons of adult and developing rats, can be used for the temporary selective degradation of the central and peripheral noradrenergic neurons, mainly those from the locus coeruleus (LC)[1][2]. |
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| Related Catalog | |
| References |
| Density | 1.338g/cm3 |
|---|---|
| Boiling Point | 276.7ºC at 760 mmHg |
| Molecular Formula | C11H16BrCl2N |
| Molecular Weight | 313.06100 |
| Exact Mass | 310.98400 |
| PSA | 3.24000 |
| LogP | 4.31180 |
| Index of Refraction | 1.551 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | DP1726100 |
| HS Code | 2921499090 |
| HS Code | 2921499090 |
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| Summary | 2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
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Noradrenergic terminals regulate L-DOPA-derived dopamine extracellular levels in a region-dependent manner in Parkinsonian rats.
CNS Neurosci. Ther. 20(7) , 671-8, (2014) Serotonin (5-HT) neurons mediate the ectopic release of dopamine (DA) induced by L-DOPA in the Parkinsonian brain. We hypothesized that the participation of noradrenalin transporters (NET) in the clea... |
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c-Fos activity mapping reveals differential effects of noradrenaline and serotonin depletion on the regulation of ocular dominance plasticity in rats.
Neuroscience 235 , 1-9, (2013) The roles of the central noradrenergic and serotonergic system in the activity-dependent regulation of ocular dominance plasticity have been a contentious issue. Using c-Fos activity mapping, we have ... |
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Effects of noradrenaline and serotonin depletions on the neuronal activity of globus pallidus and substantia nigra pars reticulata in experimental parkinsonism.
Neuroscience 202 , 424-33, (2012) Parkinson's disease (PD) is characterized by a degeneration of dopaminergic neurons and also by a degradation of noradrenergic neurons from the locus coeruleus and serotonergic neurons from the dorsal... |
| MFCD00043241 |
| N-[(2-bromophenyl)methyl]-2-chloro-N-ethylethanamine,hydrochloride |
| DSP-4 N-Ethyl-N-(2-chloroethyl)-2-bromobenzylamine hydrochloride |