O-Demethyl Lenvatinib

Modify Date: 2025-08-25 19:27:13

O-Demethyl Lenvatinib Structure
O-Demethyl Lenvatinib structure
Common Name O-Demethyl Lenvatinib
CAS Number 417717-04-5 Molecular Weight 412.826
Density 1.6±0.0 g/cm3 Boiling Point 644.1±0.0 °C at 760 mmHg
Molecular Formula C20H17ClN4O4 Melting Point N/A
MSDS N/A Flash Point 343.4±0.0 °C

 Use of O-Demethyl Lenvatinib


O-Demethyl Lenvatinib is a metabolite of Lenvatinib (HY-10981). Lenvatinib (E7080) is an oral, multi-targeted tyrosine kinase inhibitor that inhibits VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, shows potent antitumor activities[1][2].

 Names

Name 4-{3-Chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-hydroxy-6-quinolinecarboxamide
Synonym More Synonyms

 O-Demethyl Lenvatinib Biological Activity

Description O-Demethyl Lenvatinib is a metabolite of Lenvatinib (HY-10981). Lenvatinib (E7080) is an oral, multi-targeted tyrosine kinase inhibitor that inhibits VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, shows potent antitumor activities[1][2].
Related Catalog

 Chemical & Physical Properties

Density 1.6±0.0 g/cm3
Boiling Point 644.1±0.0 °C at 760 mmHg
Molecular Formula C20H17ClN4O4
Molecular Weight 412.826
Flash Point 343.4±0.0 °C
Exact Mass 412.093842
LogP 4.23
Vapour Pressure 0.0±0.0 mmHg at 25°C
Index of Refraction 1.739
Water Solubility Insuluble (6.2E-5 g/L) (25 ºC)

 Synonyms

6-Quinolinecarboxamide, 4-[3-chloro-4-[[(cyclopropylamino)carbonyl]amino]phenoxy]-7-hydroxy-
4-{3-Chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-hydroxy-6-quinolinecarboxamide
4-[3-Chloro-4-[[(cyclopropylamino)carbonyl]amino]phenoxy]-7-hydroxy-6-quinolinecarboxamide
Lenvatinib Impurity 4
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