ACAi-028

Modify Date: 2024-09-25 15:53:40

ACAi-028 Structure
ACAi-028 structure
Common Name ACAi-028
CAS Number 426224-45-5 Molecular Weight 381.204
Density N/A Boiling Point N/A
Molecular Formula C13H9BrN4O3S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of ACAi-028


ACAi-028 is a small molecule inhibiting HIV-1 replication (EC50=0.55 uM) that targets a hydrophobic pocket in the N-terminal domain of capsid (CA-NTD).ACAi-028 binds directly and noncovalently to HIV-1 capsid monomer.ACAi-028 inhibits the early stage of the HIV-1 life cycle and does not affect the late stage, also prevents multiple-round HIV-1 infection using HIV-1 strains (HIV-1NL4-3 and HIV-1LAI), except for HIV-2 strain (HIV-2ROD).ACAi-028 inhibits the replication of various types of HIV-1 strains (HIV-1104pre and HIV-1MDR/B) in PBMCs and HIV-1ATVR5μM in MT-4 cells, with negligible cytotoxicity.

 Names

Name ACAi-028

 ACAi-028 Biological Activity

Description ACAi-028 is a small molecule inhibiting HIV-1 replication (EC50=0.55 uM) that targets a hydrophobic pocket in the N-terminal domain of capsid (CA-NTD).ACAi-028 binds directly and noncovalently to HIV-1 capsid monomer.ACAi-028 inhibits the early stage of the HIV-1 life cycle and does not affect the late stage, also prevents multiple-round HIV-1 infection using HIV-1 strains (HIV-1NL4-3 and HIV-1LAI), except for HIV-2 strain (HIV-2ROD).ACAi-028 inhibits the replication of various types of HIV-1 strains (HIV-1104pre and HIV-1MDR/B) in PBMCs and HIV-1ATVR5μM in MT-4 cells, with negligible cytotoxicity.
References 1. Chia T, et al. Antimicrob Agents Chemother. 2021 Sep 17;65(10):e0103921.

 Chemical & Physical Properties

Molecular Formula C13H9BrN4O3S
Molecular Weight 381.204
Top Suppliers:I want be here


Get all suppliers and price by the below link:

ACAi-028 suppliers

ACAi-028 price