PF-63

Modify Date: 2024-04-03 10:27:29

PF-63 Structure
PF-63 structure
Common Name PF-63
CAS Number 4267-47-4 Molecular Weight 794.92700
Density 1.33g/cm3 Boiling Point 899.9ºC at 760 mmHg
Molecular Formula C43H58N2O12 Melting Point N/A
MSDS N/A Flash Point 498.1ºC

 Names

Name 3-piperidin-1-ylmethyl-rifamycin
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.33g/cm3
Boiling Point 899.9ºC at 760 mmHg
Molecular Formula C43H58N2O12
Molecular Weight 794.92700
Flash Point 498.1ºC
Exact Mass 794.39900
PSA 204.55000
LogP 5.81590
Index of Refraction 1.631
InChIKey XBZVGVKCHFRKIC-VLUCYOIHSA-N
SMILES COC1C=COC2(C)Oc3c(C)c(O)c4c(O)c(c(CN5CCCCC5)c(O)c4c3C2=O)NC(=O)C(C)=CC=CC(C)C(O)C(C)C(O)C(C)C(OC(C)=O)C1C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KD1920900
CHEMICAL NAME :
2,7-(Epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b) furan-1,11(2H)-dione, 5,6,9,17,19,21- hexahydroxy-2,4,12,16,18,20,22-heptamethyl-23-methoxy -8-(piperidinomethyl) -, 21-acetate
CAS REGISTRY NUMBER :
4267-47-4
LAST UPDATED :
199712
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C43-H58-N2-O12
MOLECULAR WEIGHT :
795.03

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CMTRAG Chemotherapia. (Basel, Switzerland) V.1-12, 1960-67. For publisher information, see CHTHBK. Volume(issue)/page/year: 12,155,1967
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
183 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
38KLAC "Structure-Activity Relationship among the Semisynthetic Antibiotics," Perlman, D., ed., New York, Academic Press, 1977 Volume(issue)/page/year: -,531,1977

 Synthetic Route

~%

PF-63 Structure

PF-63

CAS#:4267-47-4

Literature: Maggi; Arioli; Sensi Journal of medicinal chemistry, 1965 , vol. 8, # 6 p. 790 - 793

 Synonyms

3-Piperidinomethyl-rifamycin SV
3-(piperidin-1-yl-methyl)aniline
3-(Piperidylmethyl)phenylamine
[3-(piperidin-1-ylmethyl)phenyl]amine
3-(piperidinomethyl)benzenamine
3-piperidinomethyl-aniline
3-Piperidinomethyl-anilin
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.