1,3,2-Dioxathiane,4-methyl-, 2-oxide

DATA ITEMS CITED :

7

MOLECULAR FORMULA :

C4-H8-O3-S

MOLECULAR WEIGHT :

136.18

WISWESSER LINE NOTATION :

T6OSOTJ BO D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

300 mg/kg

TOXIC EFFECTS :

Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :

NCISS* Progress Report Submitted to the National Cancer Institute by South Shore Analytical and Research Laboratory. Volume(issue)/page/year: -,57,1964

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

300 mg/kg

TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :

NCISS* Progress Report Submitted to the National Cancer Institute by South Shore Analytical and Research Laboratory. Volume(issue)/page/year: -,57,1964

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

300 mg/kg

TOXIC EFFECTS :

Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :

NCISS* Progress Report Submitted to the National Cancer Institute by South Shore Analytical and Research Laboratory. Volume(issue)/page/year: -,57,1964

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

300 mg/kg

TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :

NCISS* Progress Report Submitted to the National Cancer Institute by South Shore Analytical and Research Laboratory. Volume(issue)/page/year: -,57,1964

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Mammal - cat

DOSE/DURATION :

175 mg/kg

TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :

NCISS* Progress Report Submitted to the National Cancer Institute by South Shore Analytical and Research Laboratory. Volume(issue)/page/year: -,57,1964 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

780 mg/kg/13D-I

TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold Kidney, Ureter, Bladder - hematuria Blood - changes in bone marrow (not otherwise specified)

REFERENCE :

NCISS* Progress Report Submitted to the National Cancer Institute by South Shore Analytical and Research Laboratory. Volume(issue)/page/year: -,57,1964

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Mammal - dog

DOSE/DURATION :

560 mg/kg/14D-I

TOXIC EFFECTS :

Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea Blood - changes in bone marrow (not otherwise specified)

REFERENCE :

NCISS* Progress Report Submitted to the National Cancer Institute by South Shore Analytical and Research Laboratory. Volume(issue)/page/year: -,57,1964