chlorоphentermine

Modify Date: 2026-07-10 14:41:03

chlorоphentermine structure	Common Name	chlorоphentermine
	CAS Number	461-78-9	Molecular Weight	183.67800
	Density	1.074g/cm3	Boiling Point	255.8ºC at 760mmHg
	Molecular Formula	C₁₀H₁₄ClN	Melting Point	N/A
	MSDS	N/A	Flash Point	127ºC

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	1-(4-chlorophenyl)-2-methylpropan-2-amine
Synonym	More Synonyms

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.074g/cm3
Boiling Point	255.8ºC at 760mmHg
Molecular Formula	C₁₀H₁₄ClN
Molecular Weight	183.67800
Flash Point	127ºC
Exact Mass	183.08100
PSA	26.02000
LogP	3.32010
Vapour Pressure	0.016mmHg at 25°C
Index of Refraction	1.537
InChIKey	ZCKAMNXUHHNZLN-UHFFFAOYSA-N
SMILES	CC(C)(N)Cc1ccc(Cl)cc1

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SH1050000

CHEMICAL NAME :: Phenethylamine, p-chloro-alpha,alpha-dimethyl-

CAS REGISTRY NUMBER :: 461-78-9

BEILSTEIN REFERENCE NO. :: 1099928

LAST UPDATED :: 199709

DATA ITEMS CITED :: 15

MOLECULAR FORMULA :: C10-H14-Cl-N

MOLECULAR WEIGHT :: 183.70

WISWESSER LINE NOTATION :: ZX1&1&1R DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 5357 ug/kg

TOXIC EFFECTS :: Autonomic Nervous System - sympathomimetic Vascular - BP elevation not characterized in autonomic section

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 270 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Lungs, Thorax, or Respiration - respiratory stimulation

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 260 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Lungs, Thorax, or Respiration - respiratory stimulation

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1800 mg/kg/30D-I

TOXIC EFFECTS :: Behavioral - food intake (animal) Behavioral - fluid intake Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 720 mg/kg/6W-I

TOXIC EFFECTS :: Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - changes in pulmonary vascular resistance Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1800 mg/kg/15W-I

TOXIC EFFECTS :: Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - changes in pulmonary vascular resistance Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1800 mg/kg/6W-I

TOXIC EFFECTS :: Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3900 mg/kg/13W-I

TOXIC EFFECTS :: Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - changes in pulmonary vascular resistance Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 480 mg/kg

SEX/DURATION :: female 10-21 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material) Reproductive - Specific Developmental Abnormalities - immune and reticuloendothelial system

TYPE OF TEST :: Unscheduled DNA synthesis

MUTATION DATA

TEST SYSTEM :: Rodent - rat

DOSE/DURATION :: 300 mg/kg/5D (Continuous)

REFERENCE :: 40QBA3 "Proceedings of the International Congress on Toxicology, Toxicology as a Predictive Science, 1st, Toronto, 1977," Plaa, G.L., and W.A. Duncan, eds., New York, Academic Press, Inc., 1978 Volume(issue)/page/year: -,459,1978 *** REVIEWS *** TOXICOLOGY REVIEW FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 35,89,1976

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

HS Code	29222900

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

2-chloro-N-(1-(...

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Literature: Pathway Therapeutics Inc. Patent: US2012/252802 A1, 2012 ; Location in patent: Page/Page column 77 ; US 20120252802 A1

1-(4-Chlorophen...

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Literature: Pathway Therapeutics Inc. Patent: US2012/252802 A1, 2012 ; US 20120252802 A1

N-[1-(4-chlorop...

CAS#:78558-98-2

chlorоphentermine

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Literature: Ferrari,G. Farmaco, Edizione Scientifica, 1960 , vol. 15, p. 337 - 342

4-Chlorobenzyl ...

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Literature: Ferrari,G. Farmaco, Edizione Scientifica, 1960 , vol. 15, p. 337 - 342

Methyl 4-chloro...

CAS#:52449-43-1

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Literature: Pathway Therapeutics Inc. Patent: US2012/252802 A1, 2012 ; US 20120252802 A1

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 4
CAS#:5468-97-3 1-(4-Chlorophen... CAS#:78558-98-2 N-[1-(4-chlorop... CAS#:104-83-6 4-Chlorobenzyl ... CAS#:52449-43-1 Methyl 4-chloro...
DownStream 3
CAS#:17743-62-3 N-(2-(4-Chlorop... CAS#:89516-34-7 1-(2-acetylphen... CAS#:5531-31-7 α,α-Dimethylcyc...

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2921499090
Summary	2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Binding affinity towards human GCGR in an in vitro assay with cellular components mea...
Source: ChEMBL
Target: Glucagon receptor
External Id: CHEMBL5291802

Name: Compound was evaluated for inhibition of rat Gabra1 in an in vitro assay with cellula...
Source: ChEMBL
Target: Gamma-aminobutyric acid receptor subunit alpha-1
External Id: CHEMBL5291801

Name: Binding affinity towards rat Gabra1 in an in vitro assay with cellular components mea...
Source: ChEMBL
Target: Gamma-aminobutyric acid receptor subunit alpha-1
External Id: CHEMBL5291798

Name: Binding affinity towards human ESR1 in an in vitro cell free assay (NIBR assay) measu...
Source: ChEMBL
Target: Estrogen receptor
External Id: CHEMBL5291791

Name: Binding affinity towards human ESR2 in an in vitro cell free assay measured by fluore...
Source: ChEMBL
Target: Estrogen receptor beta
External Id: CHEMBL5291793

Name: A screen for compounds that inhibit the activity of LtaS in Staphylococcus aureus
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
External Id: HMS979

Name: Binding affinity towards human EDNRB in an in vitro assay with cellular components me...
Source: ChEMBL
Target: Endothelin receptor type B
External Id: CHEMBL5291786

Name: Binding affinity towards human EDNRA in an in vitro assay with cellular components me...
Source: ChEMBL
Target: Endothelin-1 receptor
External Id: CHEMBL5291785

Name: Binding affinity towards human DRD2 in an in vitro assay with cellular components mea...
Source: ChEMBL
Target: D(2) dopamine receptor
External Id: CHEMBL5291781

Name: Binding affinity towards human CRHR2 in an in vitro assay with cellular components me...
Source: ChEMBL
Target: Corticotropin-releasing factor receptor 2
External Id: CHEMBL5291776

Total 101, Current Page 1 of 11

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

Lucofen SA

Chlorphenterminum [INN-Latin]

Effox

Chlorphenterminum

Clorfentermina [INN-Spanish]

3-(4-chlorophenyl)-2-methyl-2-propylamin

Clorfentermina

Teramine

chlorophentermine

chlorphentermine

Desopimon

1,1-dimethyl-2-(4-chlorophenyl)ethylamine

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the SMILES notation of 1-(4-chlorophenyl)-2-methylpropan-2-amine?

A: SMILES notation of 1-(4-chlorophenyl)-2-methylpropan-2-amine is CC(C)(N)Cc1ccc(Cl)cc1.

Q: What is the LogP of 1-(4-chlorophenyl)-2-methylpropan-2-amine?

A: LogP of 1-(4-chlorophenyl)-2-methylpropan-2-amine is 3.32010.

Q: What is the InChIKey of 1-(4-chlorophenyl)-2-methylpropan-2-amine?

A: InChIKey of 1-(4-chlorophenyl)-2-methylpropan-2-amine is ZCKAMNXUHHNZLN-UHFFFAOYSA-N.

Q: What English synonyms does 1-(4-chlorophenyl)-2-methylpropan-2-amine have?

A: English synonyms of 1-(4-chlorophenyl)-2-methylpropan-2-amine: Lucofen SA, Chlorphenterminum [INN-Latin], Effox, Chlorphenterminum, Clorfentermina [INN-Spanish], 3-(4-chlorophenyl)-2-methyl-2-propylamin, Clorfentermina, Teramine, chlorophentermine, chlorphentermine, Desopimon, 1,1-dimethyl-2-(4-chlorophenyl)ethylamine.

Q: What is the English name of 1-(4-chlorophenyl)-2-methylpropan-2-amine?

A: The English name of 1-(4-chlorophenyl)-2-methylpropan-2-amine is 1-(4-chlorophenyl)-2-methylpropan-2-amine.

Q: What is the molecular weight of 1-(4-chlorophenyl)-2-methylpropan-2-amine?

A: Molecular weight of 1-(4-chlorophenyl)-2-methylpropan-2-amine is 183.67800.

Q: What is the polar surface area (PSA) of 1-(4-chlorophenyl)-2-methylpropan-2-amine?

A: Polar surface area (PSA) of 1-(4-chlorophenyl)-2-methylpropan-2-amine is 26.02000.

Q: What are the downstream products of 1-(4-chlorophenyl)-2-methylpropan-2-amine?

A: Related downstream products(CAS) of 1-(4-chlorophenyl)-2-methylpropan-2-amine: 17743-62-3;89516-34-7;5531-31-7.

Q: What is the CAS number of 1-(4-chlorophenyl)-2-methylpropan-2-amine?

A: CAS number of 1-(4-chlorophenyl)-2-methylpropan-2-amine is 461-78-9.

Q: What are the upstream materials of 1-(4-chlorophenyl)-2-methylpropan-2-amine?

A: Related upstream materials(CAS) of 1-(4-chlorophenyl)-2-methylpropan-2-amine: 5468-97-3;78558-98-2;104-83-6;52449-43-1.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 2-(4-Chloro-phenyl)-1,1-dimethyl-ethylamine
Price: Check
Purity: 96.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

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