Bullatine B

Modify Date: 2024-01-02 12:31:27

Bullatine B Structure
Bullatine B structure
Common Name Bullatine B
CAS Number 466-26-2 Molecular Weight 437.570
Density 1.3±0.1 g/cm3 Boiling Point 578.3±50.0 °C at 760 mmHg
Molecular Formula C24H39NO6 Melting Point 159-161 degºC
MSDS N/A Flash Point 303.5±30.1 °C

 Use of Bullatine B


Neoline, the active ingredient of processed aconite root (PA), alleviated oxaliplatin-induced peripheral neuropathy in mice. Neoline can be used as a marker compound to determine the quality of the PA products for the treatment of neuropathic pain[1].

 Names

Name Neoline
Synonym More Synonyms

 Bullatine B Biological Activity

Description Neoline, the active ingredient of processed aconite root (PA), alleviated oxaliplatin-induced peripheral neuropathy in mice. Neoline can be used as a marker compound to determine the quality of the PA products for the treatment of neuropathic pain[1].
Related Catalog
References

[1]. Tanimura Y, et al. Neoline is the active ingredient of processed aconite root against murine peripheral neuropathic pain model, and its pharmacokinetics in rats.J Ethnopharmacol. 2019 Sep 15;241:111859.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 578.3±50.0 °C at 760 mmHg
Melting Point 159-161 degºC
Molecular Formula C24H39NO6
Molecular Weight 437.570
Flash Point 303.5±30.1 °C
Exact Mass 437.277740
PSA 91.62000
LogP -1.69
Vapour Pressure 0.0±3.6 mmHg at 25°C
Index of Refraction 1.602

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AR5569450
CHEMICAL NAME :
Aconitane-1,8,14-triol, 20-ethyl-6,16-dimethoxy-4-(methoxymethyl)-, (1-alpha,6-alpha,14- alpha,16-beta)-
CAS REGISTRY NUMBER :
466-26-2
LAST UPDATED :
199412
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C24-H39-N-O6

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 15,180,1984

 Synthetic Route

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Bullatine B Structure

Bullatine B

CAS#:466-26-2

Literature: Liang, Xihui; Desai, Haridutt K.; Joshi, Balawant S.; Pelletier, S. William Heterocycles, 1990 , vol. 31, # 10 p. 1889 - 1894

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Bullatine B Structure

Bullatine B

CAS#:466-26-2

Literature: Pelletier, S. William; Desai, Haridutt K.; Jiang, Quingping; Ross, Samir A. Phytochemistry (Elsevier), 1990 , vol. 29, # 11 p. 3649 - 3652

 Precursor & DownStream

Precursor  1

DownStream  0

 Synonyms

Xuan-Wu 3
Dideacetyldelphisine
Bullatine B
Aconitane-1,8,14-triol, 20-ethyl-6,16-dimethoxy-4-(methoxymethyl)-
20-Ethyl-6,16-dimethoxy-4-(methoxymethyl)aconitane-1,8,14-triol
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