A2ti-2

Modify Date: 2025-08-27 13:28:53

A2ti-2 Structure
A2ti-2 structure
 Common Name A2ti-2
CAS Number 482646-13-9 Molecular Weight 354.43
Density N/A Boiling Point N/A
Molecular Formula C18H18N4O2S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of A2ti-2


A2ti-2 is a selective and low-affinity annexin A2/S100A10 heterotetramer (A2t) inhibitor with an IC50 of 230 μM[1]. A2ti-2 specifically disrupts the protein-protein interaction (PPI) between A2 and S100A10. A2ti-2 prevents human papillomavirus type 16 (HPV16) infection[2].

 Names

Name A2ti-2

 A2ti-2 Biological Activity

Description A2ti-2 is a selective and low-affinity annexin A2/S100A10 heterotetramer (A2t) inhibitor with an IC50 of 230 μM[1]. A2ti-2 specifically disrupts the protein-protein interaction (PPI) between A2 and S100A10. A2ti-2 prevents human papillomavirus type 16 (HPV16) infection[2].
Related Catalog
Target

IC50: 230 μM (A2t)[1]

In Vitro A2ti-2 (compound 7a) is an annexin A2-S100A10 protein-protein interaction blocker[1]. A2ti-2 is less effective with <50% reduction in HPV16 PsV infection achieved at 100 μM. A2ti-1 decreases HPV16 entry with a 20% reduction at 100 μM[2].
References

[1]. Tummala R K Reddy, et al.Three-dimensional Pharmacophore Design and Biochemical Screening Identifies Substituted 1,2,4-triazoles as Inhibitors of the Annexin A2-S100A10 Protein Interaction. ChemMedChem. 2012 Aug;7(8):1435-46.

[2]. Andrew W Woodham, et al. Small Molecule Inhibitors of the Annexin A2 Heterotetramer Prevent Human Papillomavirus Type 16 Infection. J Antimicrob Chemother. 2015;70(6):1686-90.

 Chemical & Physical Properties

Molecular Formula C18H18N4O2S
Molecular Weight 354.43
InChIKey DRZJLOOZLBTLAL-UHFFFAOYSA-N
SMILES Cc1ccccc1OCc1nnc(SCC(N)=O)n1-c1ccccc1
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.
Top Suppliers:I want be here

Get all suppliers and price by the below link:

A2ti-2 suppliers

A2ti-2 price

Related Compounds: More...
potassium 2-(1'-ethoxy) ethoxypropanoate
100743-68-8
(1,2-dimethylpyrrolidin-2-yl)methanol
100742-04-9
N-[2-[3,4,5,6,7,8-Hexahydroazocin-1(2H)-yl]ethyl]phenylethylmalonamidic acid ethyl ester
100739-57-9
Benzaldehyde,2,3,4,5,6-pentachloro-
19635-52-0
3-(2-carboxy-5-chlorophenyl)-4-fluorobenzoic acid
1261978-66-8
3-(2-carboxy-5-fluorophenyl)-4-fluorobenzoic acid
1261927-08-5
3-(2-carboxy-4-fluorophenyl)-4-fluorobenzoic acid
1261929-13-8
3-(2-carboxy-4-methoxyphenyl)-4-fluorobenzoic acid
1261949-74-9
1-(2-hydroxy-5-tert-butyl-phenyl)ethanone
57373-81-6
1-(3-(1,2,4-Oxadiazol-3-yl)-4-phenylpyrrolidin-1-yl)-2-methoxyethanone
2034323-82-3
(3-(1,2,4-Oxadiazol-3-yl)-4-phenylpyrrolidin-1-yl)(3-methoxyphenyl)methanone
2034350-27-9
(3-(1,2,4-Oxadiazol-3-yl)-4-phenylpyrrolidin-1-yl)(5-chloro-2-methoxyphenyl)methanone
2034374-18-8
(3-(1,2,4-Oxadiazol-3-yl)-4-phenylpyrrolidin-1-yl)(4-methyl-1,2,3-thiadiazol-5-yl)methanone
2034324-02-0
(Z)-1-(3-(1,2,4-oxadiazol-3-yl)-4-phenylpyrrolidin-1-yl)-3-(pyridin-3-yl)prop-2-en-1-one
2035005-12-8
N-(3-(3-(1,2,4-oxadiazol-3-yl)-4-phenylpyrrolidine-1-carbonyl)phenyl)acetamide
2034350-51-9
3-(2-(3-(1,2,4-oxadiazol-3-yl)-4-phenylpyrrolidin-1-yl)-2-oxoethyl)-5,6-dimethylpyrimidin-4(3H)-one
2034286-06-9
3-[1-(1-methyl-1H-pyrrole-2-carbonyl)-4-phenylpyrrolidin-3-yl]-1,2,4-oxadiazole
2034350-64-4
1-(3-(1,2,4-Oxadiazol-3-yl)-4-phenylpyrrolidin-1-yl)-2-(benzo[d][1,3]dioxol-5-yl)ethanone
2034286-12-7
(3-(1,2,4-oxadiazol-3-yl)-4-phenylpyrrolidin-1-yl)(3-(1H-pyrazol-1-yl)phenyl)methanone
2034374-51-9
Chemsrc provides A2ti-2(CAS#:482646-13-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of A2ti-2 are included as well.>> amp version: A2ti-2

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved