Anagyrine

Modify Date: 2025-08-27 17:14:49

Anagyrine structure	Common Name	Anagyrine
	CAS Number	486-89-5	Molecular Weight	244.33200
	Density	1.22 g/cm3	Boiling Point	455.6ºC at 760 mmHg
	Molecular Formula	C₁₅H₂₀N₂O	Melting Point	N/A
	MSDS	N/A	Flash Point	216.3ºC

Use of Anagyrine

Anagyrine is an alkaloid that has been found in L. albus and has nematocidal and anticancer activities[1].It binds to muscarinic and nicotinic acetylcholine receptors (AChRs) with IC50 values of 132 and 2096 µM respectively[2].

Name	anagyrine
Synonym	More Synonyms

Description	Anagyrine is an alkaloid that has been found in L. albus and has nematocidal and anticancer activities[1].It binds to muscarinic and nicotinic acetylcholine receptors (AChRs) with IC50 values of 132 and 2096 µM respectively[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> GPCR/G Protein >> mAChR Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR
References	[1]. Schmeller T, Sauerwein M, Sporer F, Wink M, Müller WE. Binding of quinolizidine alkaloids to nicotinic and muscarinic acetylcholine receptors. J Nat Prod. 1994 Sep;57(9):1316-9. [2]. Matsuda, K., et al. Nematicidal activities of (–)-N-methylcytisine and (–)-anagyrine from Sophora flavescens against pine wood nematodes. Agr. BioI. Chem. 53(8), 2287-2288 (1989).

Description

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Neuronal Signaling >> mAChR

Signaling Pathways >> GPCR/G Protein >> mAChR

Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR

Signaling Pathways >> Neuronal Signaling >> nAChR

References

[1]. Schmeller T, Sauerwein M, Sporer F, Wink M, Müller WE. Binding of quinolizidine alkaloids to nicotinic and muscarinic acetylcholine receptors. J Nat Prod. 1994 Sep;57(9):1316-9.

[2]. Matsuda, K., et al. Nematicidal activities of (–)-N-methylcytisine and (–)-anagyrine from Sophora flavescens against pine wood nematodes. Agr. BioI. Chem. 53(8), 2287-2288 (1989).

Density	1.22 g/cm3
Boiling Point	455.6ºC at 760 mmHg
Molecular Formula	C₁₅H₂₀N₂O
Molecular Weight	244.33200
Flash Point	216.3ºC
Exact Mass	244.15800
PSA	25.24000
LogP	1.75780
Vapour Pressure	1.73E-08mmHg at 25°C
Index of Refraction	1.628
InChIKey	FQEQMASDZFXSJI-FRRDWIJNSA-N
SMILES	O=c1cccc2n1CC1CC2CN2CCCCC12

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BV5620000

CHEMICAL NAME :: Anagyrine

CAS REGISTRY NUMBER :: 486-89-5

BEILSTEIN REFERENCE NO. :: 0086776

LAST UPDATED :: 199709

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C15-H20-N2-O

MOLECULAR WEIGHT :: 244.37

WISWESSER LINE NOTATION :: T C66 K66 A GVN PN&TTTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 816 mg/kg

SEX/DURATION :: female 50-75 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 1,887,1976

Name: Displacement of [3H]quinuclidinyl benzilate from muscarinic ACh receptor
Source: ChEMBL
Target: N/A
External Id: CHEMBL1017387

Name: Effect on growth and morphogenesis of organogenesis-staged rat embryo at 250 ug/mL af...
Source: ChEMBL
Target: N/A
External Id: CHEMBL966342

Name: Displacement of [3H]nicotin from nicotinic ACh receptor
Source: ChEMBL
Target: N/A
External Id: CHEMBL1017386

Name: Effect on growth and morphogenesis of organogenesis-staged rat embryo at 80 ug/mL aft...
Source: ChEMBL
Target: N/A
External Id: CHEMBL966341

Name: Teratogenic activity in rat embryo assessed as incidence of major malformation at 20 ...
Source: ChEMBL
Target: N/A
External Id: CHEMBL966344

Name: Teratogenic activity in rat embryo assessed as incidence of major malformation at 5 u...
Source: ChEMBL
Target: N/A
External Id: CHEMBL966343

Name: Effect on growth and morphogenesis of organogenesis-staged rat embryo at 20 ug/mL aft...
Source: ChEMBL
Target: N/A
External Id: CHEMBL966338

Name: Effect on growth and morphogenesis of organogenesis-staged rat embryo at 5 ug/mL afte...
Source: ChEMBL
Target: N/A
External Id: CHEMBL966337

Name: Effect on growth and morphogenesis of organogenesis-staged rat embryo at 50 ug/mL aft...
Source: ChEMBL
Target: N/A
External Id: CHEMBL966339

Name: Teratogenic activity in rat embryo assessed as incidence of major malformation at 80 ...
Source: ChEMBL
Target: N/A
External Id: CHEMBL966346

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Anagyrin

Monolupine

3,4,5,6-Tetradehydrospartein-2-one

RHOMBININE

Alkaloid III

Rhombinin

Monolupin

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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Anagyrine
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Delivery: 2 Day
Contact: Liu jia
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