Kaempferide

Modify Date: 2024-01-02 11:47:15

Kaempferide structure	Common Name	Kaempferide
	CAS Number	491-54-3	Molecular Weight	300.263
	Density	1.5±0.1 g/cm3	Boiling Point	543.8±50.0 °C at 760 mmHg
	Molecular Formula	C₁₆H₁₂O₆	Melting Point	156-157ºC(lit.)
	MSDS	USA	Flash Point	207.1±23.6 °C

Use of Kaempferide

Kaempferide is an O-methylated flavonol, a type of chemical compound. It can be found in Kaempferia galanga (aromatic ginger). The enzyme kaempferol 4'-O-methyltransferase uses S-adenosyl-L-methionine and kaempferol to produce S-adenosyl-L-homocysteine and kaempferide. P-glycoproteins.

Name	kaempferide
Synonym	More Synonyms

Description	Kaempferide is an O-methylated flavonol, a type of chemical compound. It can be found in Kaempferia galanga (aromatic ginger). The enzyme kaempferol 4'-O-methyltransferase uses S-adenosyl-L-methionine and kaempferol to produce S-adenosyl-L-homocysteine and kaempferide. P-glycoproteins.
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Others >> Estrogen Receptor/ERR Natural Products >> Flavonoids Research Areas >> Others
References	[1]. Otake Y, Walle T. Oxidation of the flavonoids galangin and kaempferide by human liver microsomes and CYP1A1, CYP1A2, and CYP2C9. Drug Metab Dispos. 2002 Feb;30(2):103-5. [2]. Martineti V, Tognarini I, Azzari C et al. Inhibition of in vitro growth and arrest in the G0/G1 phase of HCT8 line human colon cancer cells by kaempferide triglycoside from Dianthus caryophyllus. Phytother Res. 2010 Sep;24(9):1302-8. [3]. Pahua-Ramos, Maria Elena; Ortiz-Moreno, Alicia; Chamorro-Cevallos, German et al. Hypolipidemic Effect of Avocado (Persea americana Mill) Seed in a Hypercholesterolemic Mouse Model. Plant Foods for Human Nutrition (New York, NY, United States) (2012), 67(1), 10-16. [4]. Soucek, Pavel; Kondrova, Eliska; Hermanek, Josef et al. New model system for testing effects of flavonoids on doxorubicin-related formation of hydroxyl radicals. Anti-Cancer Drugs (2011), 22(2), 176-184.

Description

Related Catalog

Signaling Pathways >> Autophagy >> Autophagy

Signaling Pathways >> Others >> Estrogen Receptor/ERR

Natural Products >> Flavonoids

Research Areas >> Others

References

[1]. Otake Y, Walle T. Oxidation of the flavonoids galangin and kaempferide by human liver microsomes and CYP1A1, CYP1A2, and CYP2C9. Drug Metab Dispos. 2002 Feb;30(2):103-5.

[2]. Martineti V, Tognarini I, Azzari C et al. Inhibition of in vitro growth and arrest in the G0/G1 phase of HCT8 line human colon cancer cells by kaempferide triglycoside from Dianthus caryophyllus. Phytother Res. 2010 Sep;24(9):1302-8.

[3]. Pahua-Ramos, Maria Elena; Ortiz-Moreno, Alicia; Chamorro-Cevallos, German et al. Hypolipidemic Effect of Avocado (Persea americana Mill) Seed in a Hypercholesterolemic Mouse Model. Plant Foods for Human Nutrition (New York, NY, United States) (2012), 67(1), 10-16.

[4]. Soucek, Pavel; Kondrova, Eliska; Hermanek, Josef et al. New model system for testing effects of flavonoids on doxorubicin-related formation of hydroxyl radicals. Anti-Cancer Drugs (2011), 22(2), 176-184.

Density	1.5±0.1 g/cm3
Boiling Point	543.8±50.0 °C at 760 mmHg
Melting Point	156-157ºC(lit.)
Molecular Formula	C₁₆H₁₂O₆
Molecular Weight	300.263
Flash Point	207.1±23.6 °C
Exact Mass	300.063385
PSA	100.13000
LogP	2.74
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.710
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LK6915000

CHEMICAL NAME :: Flavanone, 4'-methoxy-3,5,7-trihydroxy-

CAS REGISTRY NUMBER :: 491-54-3

BEILSTEIN REFERENCE NO. :: 0305378

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C16-H12-O6

MOLECULAR WEIGHT :: 300.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 100 ug/plate

REFERENCE :: BCSTB5 Biochemical Society Transactions. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1973- Volume(issue)/page/year: 5,1489,1977

Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	KD4170000
HS Code	29329990

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Precursor 9
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DownStream 5
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4'-O-Methylkaempferol

Kaempferol 4'-methyl ether

3,5,7-trihydroxy-2-(4-methoxyphenyl)chromen-4-one

3,5,7-Trihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one

3,5,7-trihydroxy-4'-methoxyflavone

Kaempferid

Kaempferide

3 5 7-trihydroxy-4'-methoxyflavone

4'-Methoxy-3,5,7-trihydroxyflavone

4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-(4-methoxyphenyl)-

3,5,7-trihydroxy-4′-methoxyflavone

4'-Methylkaempferol

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Kaempferide

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