Vitamin E Nicotinate

Modify Date: 2024-01-04 10:28:45

Vitamin E Nicotinate Structure
Vitamin E Nicotinate structure
Common Name Vitamin E Nicotinate
CAS Number 51898-34-1 Molecular Weight 535.800
Density 1.0±0.1 g/cm3 Boiling Point 649.0±55.0 °C at 760 mmHg
Molecular Formula C35H53NO3 Melting Point N/A
MSDS Chinese USA Flash Point 346.3±31.5 °C

 Use of Vitamin E Nicotinate


(±)-α-Tocopherol nicotinate, vitamin E - nicotinate, is an orally active fat-soluble antioxidant that prevents lipid peroxidation in cell membranes. (±)-α-Tocopherol nicotinate is hydrolysed in the blood to α -tocopherol and niacin and may be used in studies of related vascular diseases[1][2].

 Names

Name (±)-α-Tocopherol nicotinate
Synonym More Synonyms

 Vitamin E Nicotinate Biological Activity

Description (±)-α-Tocopherol nicotinate, vitamin E - nicotinate, is an orally active fat-soluble antioxidant that prevents lipid peroxidation in cell membranes. (±)-α-Tocopherol nicotinate is hydrolysed in the blood to α -tocopherol and niacin and may be used in studies of related vascular diseases[1][2].
Related Catalog
In Vitro (±)-α-Tocopherol nicotinate can help slow the progression of microangiopathy in type 2 diabetics by reducing lipid peroxidation stress in the red blood cell membrane, improving blood rheology and red blood cell deformability[1]. (±)-α-Tocopherol nicotinate (Vitamin E) (2 μg/mL, 24 h) increases the proportion of CD4+CD8-T cells in thymocytes by pretreating the thymic epithelial cell line IT45-R1 and then incubating it with immature T cells[2].
In Vivo (±)-α-Tocopherol nicotinate (Vitamin E) (in animal feedings, 50 mg/kg or 585 mg/kg, 7 weeks) significantly increases the proportion of CD4+CD8- T cells and the expression of ICAM-1 in thymic epithelial cells (TECs) isolated of male Fisher rats at high dose concentrations of 585 mg/kg compared to low dose treatment of 50 mg/kg[2].
References

[1]. T W Chung, et al. Reducing lipid peroxidation stress of erythrocyte membrane by alpha-tocopherol nicotinate plays an important role in improving blood rheological properties in type 2 diabetic patients with retinopathy. Diabet Med. 1998 May;15(5):380-5.

[2]. Satoru Moriguchi, et al.Vitamin E enhances T cell differentiation through increased epithelial cell function in rat thymus,Nutrition Research,Volume 17, Issue 5,1997,Pages 873-883.

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 649.0±55.0 °C at 760 mmHg
Molecular Formula C35H53NO3
Molecular Weight 535.800
Flash Point 346.3±31.5 °C
Exact Mass 535.402527
PSA 48.42000
LogP 13.23
Vapour Pressure 0.0±1.9 mmHg at 25°C
Index of Refraction 1.514
Storage condition 2-8°C

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
WGK Germany 3

 Articles25

More Articles
Antiarrhythmic activity of alpha-tocopherol nicotinate and related compounds and their physico-chemical properties.

Arzneimittelforschung 37(8) , 920-3, (1987)

The effect of alpha-tocopherol nicotinate (Renascin), alpha-tocopherol and dodecanoic acid (lauric acid) on the positive inotropic action of ouabain and digoxin and on cardiac glycoside induced arrhyt...

High-performance liquid chromatographic determination of alpha-tocopheryl nicotinate in cosmetic preparations.

J. Chromatogr. A. 593(1-2) , 95-7, (1992)

alpha-Tocopheryl nicotinate (alpha-TN) accelerates blood circulation and stimulates hair follicle cells, hence it is an active ingredient in a broad range of cosmetic products. A reversed-phase high-p...

Comparisons between absorption of vitamin E in patients with chronic pancreatitis and healthy controls: the bioavailability of vitamin E.

Tohoku J. Exp. Med. 148(4) , 393-401, (1986)

The fasting serum levels of alpha-tocopherol were determined by high-pressure liquid chromatography in 13 patients with chronic pancreatitis of whom 7 were positive for pancreatic calcification (CCP) ...

 Synonyms

MFCD00057302
(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-chromen-6-yl pyridine-3-carboxylate
Vitamin E nicotinate
UNII:QCP2FMP7I8
EINECS 257-501-4
(2R)-2,5,7,8-Tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-chromen-6-yl nicotinate
[2R-2R*(4R*,8R*)]-3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol nicotinate
3-Pyridinecarboxylic acid, (2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-yl ester
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