Ethybenztropine

Modify Date: 2026-07-14 21:27:36

Ethybenztropine structure	Common Name	Ethybenztropine
	CAS Number	524-83-4	Molecular Weight	321.45600
	Density	1.1g/cm3	Boiling Point	422.8ºC at 760mmHg
	Molecular Formula	C₂₂H₂₇NO	Melting Point	N/A
	MSDS	N/A	Flash Point	124ºC

Use of Ethybenztropine

Ethybenztropine (Ponalid) is a muscarinic receptor blocker. Ethybenztropine is an anticholinergic and antihistaminergic agent[1].

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	Etybenzatropine
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	Ethybenztropine (Ponalid) is a muscarinic receptor blocker. Ethybenztropine is an anticholinergic and antihistaminergic agent[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> GPCR/G Protein >> mAChR Research Areas >> Neurological Disease
Target	Muscarinic Receptor[1]
In Vitro	Ethybenztropine (10 μM) inhibits the uptake of 3H-DA in neostriatal slices.
In Vivo	Ethybenztropine (25 μg, microinjected into mesencephalic NRM) blocks the hypertherrnic response of carbachol microinjection into nucleus raphe median (NRM) of rabbits[1]. Ethybenztropine (30-60 μg/kg, administered by the fourth ventricle) is effective in preventing arrhythmias in dogs[2]. Ethybenztropine (50 mg/kg, i.p.) reduces the catecholamines accumulation in rats[3]. Animal Model: Dogs with cardiac arrhythmias[2] Dosage: 30-60 μg/kg Administration: Administered by the fourth ventricle Result: Produced slight hypotension (never exceeding a fall of 25 mm Hg) and slight sinus tachycardia. Converted arrhythmias to sinus rhythms.
References	[1]. A K Saxena, et al. Presence of cholinoceptors in mesencephalic raphe nuclei concerned in thermoregulation in rabbits. Clin Exp Pharmacol Physiol. 1984 Mar-Apr;11(2):105-10. [2]. M Rozear, et al. Effects of intracerebroventricular l-hyoscyamine, ethybenztropine and procaine on cardiac arrhythmias induced in dogs by pentylenetetrazol, picrotoxin or deslanoside. Int J Neuropharmacol. 1968 Jan;7(1):1-6. [3]. LARS-OVE FARNEBO, et al. Effect of some antiparkinsonian drugs on catecholamine neurons. Journal of Pharmacy and Pharmacology, 1970, 22(10): 733-737.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.1g/cm3
Boiling Point	422.8ºC at 760mmHg
Molecular Formula	C₂₂H₂₇NO
Molecular Weight	321.45600
Flash Point	124ºC
Exact Mass	321.20900
PSA	12.47000
LogP	4.74580
Index of Refraction	1.597
InChIKey	PHTMLLGDZBZXMW-WCRBZPEASA-N
SMILES	CCN1C2CCC1CC(OC(c1ccccc1)c1ccccc1)C2

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RD0525000

CHEMICAL NAME :: Nortropane, 3-(diphenylmethoxy)-8-ethyl-

CAS REGISTRY NUMBER :: 524-83-4

LAST UPDATED :: 199712

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C22-H27-N-O

MOLECULAR WEIGHT :: 321.50

WISWESSER LINE NOTATION :: T56 A ANTJ A2 GOYR&R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 560 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,228,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 18500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FMXXAJ French Medicament Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Discontinued. Volume(issue)/page/year: #2235M

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 66 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,228,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 12 mg/kg

TOXIC EFFECTS :: Autonomic Nervous System - parasympatholytic

REFERENCE :: EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967- Volume(issue)/page/year: 9,304,1970

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 215 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,228,1972

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 6 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,228,1972

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

HS Code	2933990090

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

Ponalide

UK-738

ethybenztropine

VK-738

Ethylbenatropine

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the SMILES notation of Etybenzatropine?

A: SMILES notation of Etybenzatropine is CCN1C2CCC1CC(OC(c1ccccc1)c1ccccc1)C2.

Q: What is the LogP of Etybenzatropine?

A: LogP of Etybenzatropine is 4.74580.

Q: What is the molecular formula of Etybenzatropine?

A: Molecular formula of Etybenzatropine is C22H27NO.

Q: What are the uses of Etybenzatropine?

A: Main uses of Etybenzatropine: Ethybenztropine (Ponalid) is a muscarinic receptor blocker. Ethybenztropine is an anticholinergic and antihistaminergic agent[1].

Q: What is the polar surface area (PSA) of Etybenzatropine?

A: Polar surface area (PSA) of Etybenzatropine is 12.47000.

Q: What English synonyms does Etybenzatropine have?

A: English synonyms of Etybenzatropine: Ponalide, UK-738, ethybenztropine, VK-738, Ethylbenatropine.

Q: What is the English name of Etybenzatropine?

A: The English name of Etybenzatropine is Etybenzatropine.

Q: What is the molecular weight of Etybenzatropine?

A: Molecular weight of Etybenzatropine is 321.45600.

Q: What is the CAS number of Etybenzatropine?

A: CAS number of Etybenzatropine is 524-83-4.

Q: What is the InChIKey of Etybenzatropine?

A: InChIKey of Etybenzatropine is PHTMLLGDZBZXMW-WCRBZPEASA-N.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Dayang Chem (Hangzhou) Co., Ltd.

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Product Name: Etybenzatropine
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