Methoxy-PEPy
Modify Date: 2026-07-01 22:31:53
Methoxy-PEPy structure
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Common Name | Methoxy-PEPy | ||
|---|---|---|---|---|
| CAS Number | 524924-76-3 | Molecular Weight | 210.23100 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C13H10N2O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Methoxy-PEPyMethoxy-PEPy is a potent and highly selective mGlu5 receptor antagonist with IC50 of 1 nM.IC50 value: 1 nM [1]Target: mGlu5R inhibitorAdministration of [3H]methoxy-PEPy (50 microCi/kg i.v.) to mGlu5 receptor-deficient mice revealed binding at background levels in forebrain, whereas wild-type mice exhibited 14-fold higher binding in forebrain relative to cerebellum [2]. The calcium transients stimulated by these agonists were potently inhibited by reference allosteric mGlu5 antagonists - 2-methyl-6-(phenylethynyl)pyridine (MPEP), 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP) and 3-methoxy-5-(pyridine-2-ylethynyl)pyridine (methoxy-PEPy) (IC(50) ranges: 0.8-66 nM) [3]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | Methoxy-PEPy |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Methoxy-PEPy is a potent and highly selective mGlu5 receptor antagonist with IC50 of 1 nM.IC50 value: 1 nM [1]Target: mGlu5R inhibitorAdministration of [3H]methoxy-PEPy (50 microCi/kg i.v.) to mGlu5 receptor-deficient mice revealed binding at background levels in forebrain, whereas wild-type mice exhibited 14-fold higher binding in forebrain relative to cerebellum [2]. The calcium transients stimulated by these agonists were potently inhibited by reference allosteric mGlu5 antagonists - 2-methyl-6-(phenylethynyl)pyridine (MPEP), 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP) and 3-methoxy-5-(pyridine-2-ylethynyl)pyridine (methoxy-PEPy) (IC(50) ranges: 0.8-66 nM) [3]. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Molecular Formula | C13H10N2O |
|---|---|
| Molecular Weight | 210.23100 |
| Exact Mass | 210.07900 |
| PSA | 35.01000 |
| LogP | 1.88500 |
| InChIKey | VRTFKUFTEWQHDD-UHFFFAOYSA-N |
| SMILES | COc1cncc(C#Cc2ccccn2)c1 |
| Storage condition | 2-8℃ |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (...
Source: NCGC
External Id: IP6K1-p1
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Name: QFRET-based biochemical primary high throughput screening assay to identify exosite i...
Source: The Scripps Research Institute Molecular Screening Center
Target: disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens]
External Id: ADAM17_INH_QFRET_1536_1X%INH PRUN
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Name: Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu...
Source: NCGC
External Id: CYP3A4437
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Name: qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in...
Source: NCGC
Target: TDP1 protein [Homo sapiens]
External Id: TDP1100
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Name: Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu...
Source: NCGC
External Id: CYP2D6395
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Name: qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in...
Source: NCGC
Target: TDP1 protein [Homo sapiens]
External Id: TDP1101
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Name: Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu...
Source: NCGC
External Id: CYP2C9536
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Name: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect...
Source: Broad Institute
Target: N/A
External Id: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity
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Name: qHTS for Inhibitors of AMA1-RON; Towards Development of Antimalarial Drug Lead: Prima...
Source: NCGC
Target: apical membrane antigen 1, AMA1 [Plasmodium falciparum 3D7]
External Id: AMA1100
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Name: Fluorescence polarization-based biochemical high throughput primary assay to identify...
Source: The Scripps Research Institute Molecular Screening Center
Target: abhydrolase domain-containing protein 4 isoform 1 [Mus musculus]
External Id: ABHD4_INH_FP_1536_1X%INH PRUN
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 3-methoxy-5-(pyridin-2-ylethynyl)pyridine |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the LogP of Methoxy-PEPy? |
| A: LogP of Methoxy-PEPy is 1.88500. |
| Q: What is the molecular formula of Methoxy-PEPy? |
| A: Molecular formula of Methoxy-PEPy is C13H10N2O. |
| Q: What is the polar surface area (PSA) of Methoxy-PEPy? |
| A: Polar surface area (PSA) of Methoxy-PEPy is 35.01000. |
| Q: What is the InChIKey of Methoxy-PEPy? |
| A: InChIKey of Methoxy-PEPy is VRTFKUFTEWQHDD-UHFFFAOYSA-N. |
| Q: What is the CAS number of Methoxy-PEPy? |
| A: CAS number of Methoxy-PEPy is 524924-76-3. |
| Q: What is the SMILES notation of Methoxy-PEPy? |
| A: SMILES notation of Methoxy-PEPy is COc1cncc(C#Cc2ccccn2)c1. |
| Q: What are the storage conditions for Methoxy-PEPy? |
| A: Storage conditions for Methoxy-PEPy: 2-8℃. |
| Q: What is the molecular weight of Methoxy-PEPy? |
| A: Molecular weight of Methoxy-PEPy is 210.23100. |
| Q: What English synonyms does Methoxy-PEPy have? |
| A: English synonyms of Methoxy-PEPy: 3-methoxy-5-(pyridin-2-ylethynyl)pyridine. |
| Q: What is the English name of Methoxy-PEPy? |
| A: The English name of Methoxy-PEPy is Methoxy-PEPy. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |