BeKm-1
Modify Date: 2025-09-26 11:22:57
BeKm-1 structure
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Common Name | BeKm-1 | ||
|---|---|---|---|---|
| CAS Number | 524962-01-4 | Molecular Weight | N/A | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C174H261N51O52S6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BeKm-1A potent, selective peptide inhibitor of hERG channel with IC50 of 3.3 nM for hERG1 channels; displays no effect at 100 nM on hEAG, hSK1, rSK2, hIK, hBK, KCNQ1/KCNE1, KCNQ2/KCNQ3, KCNQ4 channels, and minimal effect on rELK1; prolongs QTc intervals significantly and concentration-dependently (4.7 and 16.3% at 10 and 100 nM, respectively). |
| Name | BeKm 1 |
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| Description | A potent, selective peptide inhibitor of hERG channel with IC50 of 3.3 nM for hERG1 channels; displays no effect at 100 nM on hEAG, hSK1, rSK2, hIK, hBK, KCNQ1/KCNE1, KCNQ2/KCNQ3, KCNQ4 channels, and minimal effect on rELK1; prolongs QTc intervals significantly and concentration-dependently (4.7 and 16.3% at 10 and 100 nM, respectively). |
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| References | References 1. Korolkova YV, et al. J Biol Chem. 2002 Nov 8;277(45):43104-9. 2. Korolkova YV, et al. J Biol Chem. 2001 Mar 30;276(13):9868-76. 3. Qu Y, et al. J Pharmacol Exp Ther. 2011 Apr;337(1):2-8. 4. Qu Y, et al. J Pharmacol Exp Ther. 2011 Apr;337(1):2-8. View Related Products by Target Potassium Channel |
| Molecular Formula | C174H261N51O52S6 |
|---|---|
| InChIKey | OQEMUGXECXBKDP-UHFFFAOYSA-N |
| SMILES | CCC(C)C(NC(=O)C(CC(=O)O)NC(=O)C(NC(=O)C1CCCN1C(=O)C(N)CCCNC(=N)N)C(C)O)C(=O)NC(CCCCN)C(=O)NC1CSSCC2NC(=O)C(CCCNC(=N)N)NC(=O)CNC(=O)C(CC(N)=O)NC(=O)C(C(C)O)NC(=O)C(CCCCN)NC(=O)CNC(=O)C(Cc3ccccc3)NC(=O)C(CCCNC(=N)N)NC(=O)C(CO)NC(=O)C(CCCCN)NC(=O)C3CSSCC(C(=O)NC(Cc4ccccc4)C(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(CSSCC(NC(=O)C(CCC(N)=O)NC(=O)C(Cc4ccc(O)cc4)NC(=O)C(CO)NC(=O)C(CCC(=O)O)NC(=O)C(CO)NC1=O)C(=O)NC(Cc1ccccc1)C(=O)N1CCCC1C(=O)NC(C(C)C)C(=O)N3)NC(=O)C(Cc1ccccc1)NC(=O)CNC(=O)C(CC(N)=O)NC(=O)C(C(C)C)NC2=O |