bPiDDB

Modify Date: 2025-08-26 09:35:03

bPiDDB structure	Common Name	bPiDDB
	CAS Number	525596-66-1	Molecular Weight	514.38000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₃₈Br₂N₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of bPiDDB

bPiDDB is a potent nAChR antagonist. bPiDDB potently (IC50=2 nM) inhibits nicotine-evoked striatal dopamine (DA) release through an interaction with α6β2-containing nAChRs[1].

Name	1,1'-(1,12-Dodecanediyl)bis(3-methylpyridinium) dibromide

Description	bPiDDB is a potent nAChR antagonist. bPiDDB potently (IC50=2 nM) inhibits nicotine-evoked striatal dopamine (DA) release through an interaction with α6β2-containing nAChRs[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Neurological Disease
In Vivo	bPiDDB (外周给药) 可抑制伏隔核中尼古丁诱发的多巴胺 (DA) 释放，降低大鼠尼古丁的成瘾性[1]。 bPiDDB 在外周给药后具有脑生物可利用性，并由血脑屏障胆碱转运体主动运输到中央室[1]。
References	[1]. Smith AM, et al. Repeated nicotine administration robustly increases bPiDDB inhibitory potency at alpha6beta2-containing nicotinic receptors mediating nicotine-evoked dopamine release. Biochem Pharmacol. 2010 Aug 1;80(3):402-9.

Molecular Formula	C₂₄H₃₈Br₂N₂
Molecular Weight	514.38000
Exact Mass	512.14000
PSA	7.76000

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: bPiDDB
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Purity: 98.72%
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bPiDDB

Use of bPiDDB

Names

bPiDDB Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.