Galgravin

Modify Date: 2025-08-25 10:36:15

Galgravin Structure
Galgravin structure
Common Name Galgravin
CAS Number 528-63-2 Molecular Weight 372.45500
Density N/A Boiling Point N/A
Molecular Formula C22H28O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Galgravin


Galgravin is an active compound in Nectandra megapotamica, with anti-inflammatory activity. Galgravin displays in vitro cytotoxic activity and induce apoptosis in leukemia cells[1][2].

 Names

Name galgravin
Synonym More Synonyms

 Galgravin Biological Activity

Description Galgravin is an active compound in Nectandra megapotamica, with anti-inflammatory activity. Galgravin displays in vitro cytotoxic activity and induce apoptosis in leukemia cells[1][2].
Related Catalog
In Vitro Galgravin has cytotoxic activity against human leukemia tumor cells with an IC50 of 16.5 µg/mL[2].
References

[1]. da Silva Filho AA, et al. Evaluation of analgesic and anti-inflammatory activities of Nectandra megapotamica (Lauraceae) in mice and rats. J Pharm Pharmacol. 2004 Sep;56(9):1179-84.

[2]. Ponci V, et al. Neolignans from Nectandra megapotamica (Lauraceae) Display in vitro Cytotoxic Activity and Induce Apoptosis in Leukemia Cells. Molecules. 2015 Jul 15;20(7):12757-68.

 Chemical & Physical Properties

Molecular Formula C22H28O5
Molecular Weight 372.45500
Exact Mass 372.19400
PSA 46.15000
LogP 4.80580
InChIKey JLJAVUZBHSLLJL-DQEHQXCCSA-N
SMILES COc1ccc(C2OC(c3ccc(OC)c(OC)c3)C(C)C2C)cc1OC

 GalgravinBioassay

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Name: Neuroprotective activity against Abeta (25 to 35)-induced cytotoxicity in human SH-SY...
Source: ChEMBL
Target: SH-SY5Y
External Id: CHEMBL4178590
Name: Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro...
Source: NCGC
Target: N/A
External Id: SERCaMPGLuc-p1-antagonist
Name: Neuroprotective activity against Abeta (25 to 35)-induced cytotoxicity in human SH-SY...
Source: ChEMBL
Target: SH-SY5Y
External Id: CHEMBL4178591
Name: Neuroprotective activity against Abeta (25 to 35)-induced cytotoxicity in human SH-SY...
Source: ChEMBL
Target: SH-SY5Y
External Id: CHEMBL4178586
Name: Selectivity index, ratio of CC50 for human C8166 cells to EC50 for HIV1 3B
Source: ChEMBL
Target: N/A
External Id: CHEMBL1058084
Name: Cytotoxicity against human C8166 cells by MTT assay
Source: ChEMBL
Target: C8166
External Id: CHEMBL1058082
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 Synonyms

Galgravin
r-2,c-5-Bis(3,4-dimethoxyphenyl)-t-3,t-4-dimethyl-tetrahydrofuran
2r,5cBis-(3,4-dimethoxy-phenyl)-3t,4t-dimethyl-tetrahydro-furan
(2S,3S,4R,5R)-2,5-Bis-(3,4-dimethoxy-phenyl)-3,4-dimethyl-tetrahydro-furan
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