Tetrahydrocortisone

Modify Date: 2025-08-25 19:32:18

Tetrahydrocortisone Structure
Tetrahydrocortisone structure
Common Name Tetrahydrocortisone
CAS Number 53-05-4 Molecular Weight 364.47600
Density 1.249g/cm3 Boiling Point 544.5ºC at 760mmHg
Molecular Formula C21H32O5 Melting Point 190°C
MSDS USA Flash Point 297.1ºC

 Use of Tetrahydrocortisone


Tetrahydrocortisone is a stress-induced hormone. Tetrahydrocortisone is also a urinary metabolite of Cortisone derived from the reduction of Cortisone by 5-reductase[1].

 Names

Name Tetrahydro Cortisone
Synonym More Synonyms

 Tetrahydrocortisone Biological Activity

Description Tetrahydrocortisone is a stress-induced hormone. Tetrahydrocortisone is also a urinary metabolite of Cortisone derived from the reduction of Cortisone by 5-reductase[1].
Related Catalog
References

[1]. Thiam Chye TAN, et al. Characteristic metabolites in miscarriages. WO2018199849A1.

 Chemical & Physical Properties

Density 1.249g/cm3
Boiling Point 544.5ºC at 760mmHg
Melting Point 190°C
Molecular Formula C21H32O5
Molecular Weight 364.47600
Flash Point 297.1ºC
Exact Mass 364.22500
PSA 94.83000
LogP 1.86150
Index of Refraction 1.569
InChIKey SYGWGHVTLUBCEM-ZIZPXRJBSA-N
SMILES CC12CCC(O)CC1CCC1C2C(=O)CC2(C)C1CCC2(O)C(=O)CO
Storage condition -20°C

 Precursor & DownStream

Precursor  0

DownStream  1

 TetrahydrocortisoneBioassay

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Name: Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimo...
Source: ChEMBL
Target: Solute carrier organic anion transporter family member 1B1
External Id: CHEMBL3039488
Name: Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimo...
Source: ChEMBL
Target: Solute carrier organic anion transporter family member 1B3
External Id: CHEMBL3039491
Name: Human Phosphogluconate dehydrogenase (6PGD) Inhibitor Screening
Source: 11827
Target: Phosphogluconate dehydrogenase
External Id: 6PGD_Inhibitor_Screening_2015_09
Total 3, Current Page 1 of 1
1

 Synonyms

(3R,5R,8S,9S,10S,13S,14S,17R)-3,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,3,4,5,6,7,8,9,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-11-one
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