Sultopride
Sultopride structure
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Common Name | Sultopride | ||
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| CAS Number | 53583-79-2 | Molecular Weight | 354.46400 | |
| Density | 1.16g/cm3 | Boiling Point | 530ºC at 760mmHg | |
| Molecular Formula | C17H26N2O4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 274.3ºC | |
Use of SultoprideSultopride is a selective antagonist of dopamine D2 receptor. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | Sultopride |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Sultopride is a selective antagonist of dopamine D2 receptor. |
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| Related Catalog | |
| Target |
Dopamine D2 receptor[1] |
| In Vivo | Sultopride is a selective antagonist of dopamine D2 receptor. DOPAC and HVA levels in the striatum, the nucleus accumbens and the medial prefrontal cortex are higher in the rats treated with Sultopride and sulpiride than those of the controls. In the striatum, DOPAC and HVA levels are higher in the Sultopride-treated rats than the sulpiride-treated rats (p<0.05). In the nucleus accumbens, DOPAC levels are higher in the Sultopride-treated rats than sulpiride treated rats (p<0.05). In the Sultopride-treated rats, DOPAC and HVA levels are higher in the striatum or in the nucleus accumbens than in the medial prefrontal cortex (p<0.05)[1]. |
| Animal Admin | Thirty-six male Sprague-Dawley rats weighing 180 to 220 g are used in this study. The rats are divided into three groups of 6 each. One group is intraperitoneally injected with Sultopride (100 mg/kg body weight), the second group with sulphide (100 mg/kg body weight), and the third group with normal saline. One hundred minutes after the initial treatments, apomorphine (0.1 mg/kg body weight, dissolved in saline ad libitum) is administered subcutaneously to the three groups, and 20 minutes later the rats are sacrificed. The third group serves as controls[1]. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.16g/cm3 |
|---|---|
| Boiling Point | 530ºC at 760mmHg |
| Molecular Formula | C17H26N2O4S |
| Molecular Weight | 354.46400 |
| Flash Point | 274.3ºC |
| Exact Mass | 354.16100 |
| PSA | 84.09000 |
| LogP | 3.11250 |
| InChIKey | UNRHXEPDKXPRTM-UHFFFAOYSA-N |
| SMILES | CCN1CCCC1CNC(=O)c1cc(S(=O)(=O)CC)ccc1OC |
| Storage condition | 2-8℃ |
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| HS Code | 2933990090 |
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This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Compound was evaluated for inhibition of rat Gabra1 in an in vitro assay with cellula...
Source: ChEMBL
Target: Gamma-aminobutyric acid receptor subunit alpha-1
External Id: CHEMBL5291801
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Name: Agonist activity at human GABRA1 in an in vitro cell-based assay measured by fluoresc...
Source: ChEMBL
Target: Gamma-aminobutyric acid receptor subunit gamma-2
External Id: CHEMBL5291796
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Name: Binding affinity towards rat Gabra1 in an in vitro assay with cellular components mea...
Source: ChEMBL
Target: Gamma-aminobutyric acid receptor subunit alpha-1
External Id: CHEMBL5291798
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Name: Human intestinal absorption in po dosed human
Source: ChEMBL
Target: Homo sapiens
External Id: CHEMBL1116254
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Name: Antagonist activity at human GABRA1 in an in vitro cell-based assay measured by fluor...
Source: ChEMBL
Target: Gamma-aminobutyric acid receptor subunit gamma-2
External Id: CHEMBL5291797
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Name: Binding affinity towards human ESR1 in an in vitro cell free assay (NIBR assay) measu...
Source: ChEMBL
Target: Estrogen receptor
External Id: CHEMBL5291791
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Name: Binding affinity towards human HRH3 in an in vitro assay with cellular components mea...
Source: ChEMBL
Target: Histamine H3 receptor
External Id: CHEMBL5291921
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Name: Subcutaneous dose to inhibit apomorphine-induced stereotyped behavior in 50% of rats
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL779011
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Name: Binding affinity towards human EDNRA in an in vitro assay with cellular components me...
Source: ChEMBL
Target: Endothelin-1 receptor
External Id: CHEMBL5291785
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Name: Binding affinity towards human DRD2 in an in vitro assay with cellular components mea...
Source: ChEMBL
Target: D(2) dopamine receptor
External Id: CHEMBL5291781
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| LIN 1418 |
| Barnetil |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the CAS number of Sultopride? |
| A: CAS number of Sultopride is 53583-79-2. |
| Q: What are the storage conditions for Sultopride? |
| A: Storage conditions for Sultopride: 2-8℃. |
| Q: What is the SMILES notation of Sultopride? |
| A: SMILES notation of Sultopride is CCN1CCCC1CNC(=O)c1cc(S(=O)(=O)CC)ccc1OC. |
| Q: What is the InChIKey of Sultopride? |
| A: InChIKey of Sultopride is UNRHXEPDKXPRTM-UHFFFAOYSA-N. |
| Q: What is the molecular formula of Sultopride? |
| A: Molecular formula of Sultopride is C17H26N2O4S. |
| Q: What is the molecular weight of Sultopride? |
| A: Molecular weight of Sultopride is 354.46400. |
| Q: What are the uses of Sultopride? |
| A: Main uses of Sultopride: Sultopride is a selective antagonist of dopamine D2 receptor. |
| Q: What is the English name of Sultopride? |
| A: The English name of Sultopride is Sultopride. |
| Q: What is the polar surface area (PSA) of Sultopride? |
| A: Polar surface area (PSA) of Sultopride is 84.09000. |
| Q: What is the boiling point of Sultopride? |
| A: Boiling point of Sultopride is 530ºC at 760mmHg. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |