N'-propan-2-ylpyridine-4-carbohydrazide

Modify Date: 2026-07-10 06:42:30

N'-propan-2-ylpyridine-4-carbohydrazide structure	Common Name	N'-propan-2-ylpyridine-4-carbohydrazide
	CAS Number	54-92-2	Molecular Weight	179.21900
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₉H₁₃N₃O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of N'-propan-2-ylpyridine-4-carbohydrazide

Iproniazid is a non-selective, irreversible monoamine oxidase (MAO) inhibitor of the hydrazine class. Iproniazid has antidepressive activity[1].

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	iproniazid
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	Iproniazid is a non-selective, irreversible monoamine oxidase (MAO) inhibitor of the hydrazine class. Iproniazid has antidepressive activity[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Research Areas >> Neurological Disease
References	[1]. Fagervall I, et al. Inhibition of monoamine oxidase in monoaminergic neurones in the rat brain by irreversible inhibitors. Biochemical pharmacology 35 (8): 1381–1387

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Molecular Formula	C₉H₁₃N₃O
Molecular Weight	179.21900
Exact Mass	179.10600
PSA	54.02000
LogP	1.50620
InChIKey	NYMGNSNKLVNMIA-UHFFFAOYSA-N
SMILES	CC(C)NNC(=O)c1ccncc1

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

N'-propan-2-ylpyridine-4-carbohydrazide MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NS1925000

CHEMICAL NAME :: Isonicotinic acid, 2-isopropylhydrazide

CAS REGISTRY NUMBER :: 54-92-2

BEILSTEIN REFERENCE NO. :: 0142700

LAST UPDATED :: 199612

DATA ITEMS CITED :: 26

MOLECULAR FORMULA :: C9-H13-N3-O

MOLECULAR WEIGHT :: 179.25

WISWESSER LINE NOTATION :: T6NJ DVMMY1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 2143 ug/kg/D

TOXIC EFFECTS :: Gastrointestinal - decreased motility or constipation Kidney, Ureter, Bladder - urine volume decreased Nutritional and Gross Metabolic - other changes

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 14 mg/kg/2W-I

TOXIC EFFECTS :: Liver - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 365 mg/kg

TOXIC EFFECTS :: Behavioral - toxic psychosis

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 375 mg/kg

TOXIC EFFECTS :: Behavioral - anticonvulsant

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 538 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 350 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 681 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 475 mg/kg

TOXIC EFFECTS :: Behavioral - anticonvulsant

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 730 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 719 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 615 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 95 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 640 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 125 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 117 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1050 mg/kg/5W-I

TOXIC EFFECTS :: Behavioral - excitement Skin and Appendages - hair Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 60 mg/kg/6D-I

TOXIC EFFECTS :: Autonomic Nervous System - sympathomimetic Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - monoamine oxidase

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10 gm/kg/36W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 45 mg/kg

SEX/DURATION :: male 21 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - impotence

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 75 mg/kg

SEX/DURATION :: male 3 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 20 mg/kg

SEX/DURATION :: female 4-7 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 1200 mg/kg

SEX/DURATION :: female 6-11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 1200 mg/kg

SEX/DURATION :: female 11-16 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - stillbirth

MUTATION DATA

TYPE OF TEST :: DNA repair

TEST SYSTEM :: Bacteria - Escherichia coli

DOSE/DURATION :: 250 ug/well

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 133,161,1984 *** REVIEWS *** TOXICOLOGY REVIEW MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 39,111,1977

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

HS Code	2933399090

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

1(Or 2)-(isopro...

CAS#:4813-04-1

~92%

N'-propan-2-ylp...

CAS#:54-92-2

Learn More

Literature: Vigorita; Ottana; Maccari; Monforte; Bisignano; Pizzimenti Bollettino Chimico Farmaceutico, 1998 , vol. 137, # 7 p. 267 - 276

Isoniazid

CAS#:54-85-3

N'-propan-2-ylp...

CAS#:54-92-2

Learn More

Literature: Journal of the American Chemical Society, , vol. 75, p. 1933,1934 Journal of the American Pharmaceutical Association (1912-1977), , vol. 42, p. 457,463

2-Iodopropane

CAS#:75-30-9

Isoniazid

CAS#:54-85-3

N'-propan-2-ylp...

CAS#:54-92-2

Learn More

Literature: Gazzetta Chimica Italiana, , vol. 88, p. 393,398

Isoniazid

CAS#:54-85-3

2-Bromopropane

CAS#:75-26-3

N'-propan-2-ylp...

CAS#:54-92-2

Learn More

Literature: Journal of the American Pharmaceutical Association (1912-1977), , vol. 42, p. 457,463

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 4
CAS#:4813-04-1 1(Or 2)-(isopro... CAS#:54-85-3 Isoniazid CAS#:75-30-9 2-Iodopropane CAS#:75-26-3 2-Bromopropane
DownStream 0

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

N'-Isopropylisonicotinohydrazide

IPRAZID

isonicotinic acid N'-isopropyl-hydrazide

N'-propan-2-ylpyridine-4-carbohydrazide

iproniziazid

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the polar surface area (PSA) of iproniazid?

A: Polar surface area (PSA) of iproniazid is 54.02000.

Q: What is the English name of iproniazid?

A: The English name of iproniazid is iproniazid.

Q: What is the molecular weight of iproniazid?

A: Molecular weight of iproniazid is 179.21900.

Q: What are the upstream materials of iproniazid?

A: Related upstream materials(CAS) of iproniazid: 4813-04-1;54-85-3;75-30-9;75-26-3.

Q: What is the CAS number of iproniazid?

A: CAS number of iproniazid is 54-92-2.

Q: What English synonyms does iproniazid have?

A: English synonyms of iproniazid: N'-Isopropylisonicotinohydrazide, IPRAZID, isonicotinic acid N'-isopropyl-hydrazide, N'-propan-2-ylpyridine-4-carbohydrazide, iproniziazid.

Q: What is the InChIKey of iproniazid?

A: InChIKey of iproniazid is NYMGNSNKLVNMIA-UHFFFAOYSA-N.

Q: What is the molecular formula of iproniazid?

A: Molecular formula of iproniazid is C9H13N3O.

Q: What is the SMILES notation of iproniazid?

A: SMILES notation of iproniazid is CC(C)NNC(=O)c1ccncc1.

Q: What is the LogP of iproniazid?

A: LogP of iproniazid is 1.50620.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Dayang Chem (Hangzhou) Co., Ltd.

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: N'-propan-2-ylpyridine-4-carbohydrazide
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: iproniazid
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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N'-propan-2-ylpyridine-4-carbohydrazide suppliers

Price: ￥550/10 mM * 1 mL in DMSO

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N'-propan-2-ylpyridine-4-carbohydrazide

Use of N'-propan-2-ylpyridine-4-carbohydrazide

Names