Zorubicin

Modify Date: 2025-08-26 15:41:23

Zorubicin structure	Common Name	Zorubicin
	CAS Number	54083-22-6	Molecular Weight	645.65600
	Density	1.54g/cm3	Boiling Point	N/A
	Molecular Formula	C₃₄H₃₅N₃O₁₀	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Zorubicin

Zorubicin (Rubidazon) is a derivative of Daunorubicin (HY-13062A). Zorubicin interacts with topoisomerase II and inhibits DNA polymerases. Zorubicin can be used for the research of acute leukemias and sarcomas[1][2][3][4][5].

Name	N-[(E)-1-[(2S,4S)-4-(4-amino-5-hydroxy-6-methyloxan-2-yl)oxy-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-3,4-dihydro-1H-tetracen-2-yl]ethylideneamino]benzamide
Synonym	More Synonyms

Description	Zorubicin (Rubidazon) is a derivative of Daunorubicin (HY-13062A). Zorubicin interacts with topoisomerase II and inhibits DNA polymerases. Zorubicin can be used for the research of acute leukemias and sarcomas[1][2][3][4][5].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
In Vitro	Zorubicin (0.1-1 μg/mL; 0-24 h) affects cell cycle[2]. Zorubicin (0-128 nM/mL; 20 min) dose-dependently inhibits DNA polymerases α and β, and shows preferential inhibition of polymerase α[3]. Cell Cycle Analysis[2]. Cell Line: Human lymphoid cell line Concentration: 0.1-1 μg/mL Incubation Time: 0-24 hours Result: Time-dependently increased G2-accumulations of human lymphoid cells, delayed the traverse through G1 and the G1-S transition. Caused a stepwise accumulation of cells in G2-phase.
In Vivo	Zorubicin (12-18 mg/kg; i.p. 48 h after tumour cells injection) affects leukaemic colony forming units[1]. Zorubicin (0.75-6.0 mg/kg; i.v.) increases plasma histamine concentrations and produces immediate hypotension in anesthetized beagle dogs[3]. Animal Model: Six- to eight-week-old male DBA2 mice with P388 tumour cells[1] Dosage: 12-18 mg/kg Administration: Intraperitoneal injection ; 12-18 mg/kg; 48 h after tumour cells injection Result: Showed a D1/2 value of 1.6 mg/kg for leukaemic colony forming units.

Density	1.54g/cm3
Molecular Formula	C₃₄H₃₅N₃O₁₀
Molecular Weight	645.65600
Exact Mass	645.23200
PSA	210.23000
LogP	3.33700

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG3345000

CHEMICAL NAME :: Benzoic acid, (1-(4-((3-amino-2,3,6-trideoxy-alpha,L-lyxo-hexopyran osyl)oxy)-1,2,3,4,6,1 1- hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-na phthacenyl)ethylidene )hydrazide, (2S-cis)-

CAS REGISTRY NUMBER :: 54083-22-6

LAST UPDATED :: 199703

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C34-H35-N3-O10

MOLECULAR WEIGHT :: 645.72

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 35 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 22500 ug/kg/5D-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 75 mg/kg/5D-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 42500 ug/kg/5D-I

TOXIC EFFECTS :: Related to Chronic Data - death

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - rat Cells - not otherwise specified

DOSE/DURATION :: 2150 ug/L

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 38,167,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2089 No. of Facilities: 8 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 229 (estimated) No. of Female Employees: 82 (estimated)

Rubidazone

ZORUBICIN

Zorubicina [INN-Spanish]

zorubicine

Benzoylhydrazone daunorubicin

Zorubicin [INN]

daunomycin benzoylhydrazone

Zorubicine [INN-French]

Rubidazon

Zorubicinum [INN-Latin]

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Zorubicin
Price: Check
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DC Chemicals Limited
China
Product Name: Zorubicin
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Delivery: 10 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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Zorubicin Biological Activity

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.