Nizofenone
Modify Date: 2024-01-10 21:43:21
Nizofenone structure
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Common Name | Nizofenone | ||
|---|---|---|---|---|
| CAS Number | 54533-85-6 | Molecular Weight | 412.869 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 609.7±65.0 °C at 760 mmHg | |
| Molecular Formula | C21H21ClN4O3 | Melting Point | 75-76° | |
| MSDS | N/A | Flash Point | 322.5±34.3 °C | |
Use of NizofenoneNizofenone is a neuroprotective agent which protects neurons from death following cerebral ischemia or anoxia. Nizofenone can be used in the research of acute neurological conditions, such as stroke[1][2][3]. |
| Name | Nizofenone |
|---|---|
| Synonym | More Synonyms |
| Description | Nizofenone is a neuroprotective agent which protects neurons from death following cerebral ischemia or anoxia. Nizofenone can be used in the research of acute neurological conditions, such as stroke[1][2][3]. |
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| Related Catalog | |
| In Vitro | Nizofenone (1 and 10 μM) prolongs the action potential duration of guinea-pig papillary muscle and dog Purkinje fibers[3]. Nizofenone (30 μM) suppresses the spontaneous activity of dog Purkinje fibers and guinea-pigs S-A node[3]. Nizofenone (100 μM) decreases the contractile force of guinea-pig papillary muscle[3]. Nizofenone (10 μM) inhibits the peroxidative disintegration of mitochondria (in rat brain mitochondrial suspension)[4]. |
| In Vivo | Nizofenone (3 and 9 mg/kg, i.p., daily) attenuates the chronic restraint stress (CRS)-induced cognitive impairments[1]. Nizofenone (10 mg/kg i.p.) inhibits ischemia-induced glutamate increase and lactate increase in the hippocampus of rats[2]. Animal Model: Mice with chronic restraint stress[1] Dosage: 3, 9 mg/kg Administration: Intraperitoneal injection (i.p.), daily Result: Increased crossing frequencies of the open field test. Increased in the activities of enzymatic SOD and CAT. |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 609.7±65.0 °C at 760 mmHg |
| Melting Point | 75-76° |
| Molecular Formula | C21H21ClN4O3 |
| Molecular Weight | 412.869 |
| Flash Point | 322.5±34.3 °C |
| Exact Mass | 412.130219 |
| PSA | 83.95000 |
| LogP | 4.25 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.623 |
| HS Code | 2933290090 |
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| HS Code | 2933290090 |
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| Summary | 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| Nizofenone |
| Ekonal |
| EkonN |
| (2-Chlorophenyl)(2-{2-[(diethylamino)methyl]-1H-imidazol-1-yl}-5-nitrophenyl)methanone |
| (2-Chlorophenyl)[2-[2-[(diethylamino)methyl]-1H-imidazol-1-yl]-5-nitrophenyl]methanone |
| Y-9179 |
| 2'-Chloro-2-[2-[(diethylamino)methyl]imidazol-1-yl]-5-nitrobenzophenone |
| Midafenone |
| Methanone, (2-chlorophenyl)[2-[2-[(diethylamino)methyl]-1H-imidazol-1-yl]-5-nitrophenyl]- |