2-(2,6-dioxopiperidin-3-yl)-5-nitroisoindoline-1,3-dione

Modify Date: 2024-01-10 14:24:42

2-(2,6-dioxopiperidin-3-yl)-5-nitroisoindoline-1,3-dione structure	Common Name	2-(2,6-dioxopiperidin-3-yl)-5-nitroisoindoline-1,3-dione
	CAS Number	55003-81-1	Molecular Weight	303.23
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₃H₉N₃O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 2-(2,6-dioxopiperidin-3-yl)-5-nitroisoindoline-1,3-dione

CRBN ligand-9 (Compound 4d) is a CRBN ligand (Ki: 8.9 μM). CRBN ligand-9 can be used for synthesis of PROTACs[1][2].

Name	2-(2,6-dioxopiperidin-3-yl)-5-nitroisoindole-1,3-dione
Synonym	More Synonyms

Description	CRBN ligand-9 (Compound 4d) is a CRBN ligand (Ki: 8.9 μM). CRBN ligand-9 can be used for synthesis of PROTACs[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> Ligand for E3 Ligase
References	[1]. Heim C,et al. De-Novo Design of Cereblon (CRBN) Effectors Guided by Natural Hydrolysis Products of Thalidomide Derivatives. J Med Chem. 2019 Jul 25;62(14):6615-6629. [2]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Description

CRBN ligand-9 (Compound 4d) is a CRBN ligand (Ki: 8.9 μM). CRBN ligand-9 can be used for synthesis of PROTACs[1][2].

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> Ligand for E3 Ligase

References

[1]. Heim C,et al. De-Novo Design of Cereblon (CRBN) Effectors Guided by Natural Hydrolysis Products of Thalidomide Derivatives. J Med Chem. 2019 Jul 25;62(14):6615-6629.

[2]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Molecular Formula	C₁₃H₉N₃O₆
Molecular Weight	303.23
Exact Mass	303.04900
PSA	132.86000
LogP	0.73300
Storage condition	2-8℃

4-Nitrophthalic...

CAS#:5466-84-2

3-Amino-2,6-pip...

CAS#:24666-56-6

~53%

2-(2,6-dioxopip...

CAS#:55003-81-1

Literature: Celgene Corporation Patent: US6335/349 B1, 2002 ; Location in patent: Example 2 ; Title/Abstract Full Text Show Details Celgene Corporation Patent: US6335349 B1, 2002 ; Location in patent: Example 2 ;

Z-Gln-OH

CAS#:2650-64-8

2-(2,6-dioxopip...

CAS#:55003-81-1

Literature: Muller, George W.; Chen, Roger; Huang, Shaei-Yun; Corral, Laura G.; Wong, Lu Min; Patterson, Rebecca T.; Chen, Yuxi; Kaplan, Gilla; Stirling, David I. Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 11 p. 1625 - 1630

Benzyl (2,6-dio...

CAS#:24666-55-5

2-(2,6-dioxopip...

CAS#:55003-81-1

4-Nitrophthalic...

CAS#:5466-84-2

3-aminopiperidi...

CAS#:2353-44-8

2-(2,6-dioxopip...

CAS#:55003-81-1

Literature: Contino-Pepin, Christiane; Parat, Audrey; Perino, Sandrine; Lenoir, Christine; Vidal, Michel; Galons, Herve; Karlik, Stephen; Pucci, Bernard Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 3 p. 878 - 881

Precursor 5
CAS#:5466-84-2 4-Nitrophthalic... CAS#:24666-56-6 3-Amino-2,6-pip... CAS#:2650-64-8 Z-Gln-OH CAS#:24666-55-5 Benzyl (2,6-dio...
CAS#:2353-44-8 3-aminopiperidi...
DownStream 1
CAS#:191732-76-0 5-amino-2-(2,6-...

4-nitrothalidomide

2-(2,6-dioxo-3-piperidinyl)-5-nitro-1H-isoindole-1,3(2H)-dione

2-(2,6-dioxo-piperidin-3-yl)-5-nitro-isoindole-1,3-dione

1H-Isoindole-1,3(2H)-dione,2-(2,6-dioxo-3-piperidinyl)-5-nitro

2-(4'-Nitro-phthalimido)-glutarimid

1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)-5-nitroisoindoline

N-(2,6-dioxopiperidin-3-yl)-4-nitrophthalimide

2-(2,6-dioxopiperidin-3-yl)-5-nitroisoindoline-1,3-dione

Use of 2-(2,6-dioxopiperidin-3-yl)-5-nitroisoindoline-1,3-dione

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Precursor & DownStream

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