CHEMICAL IDENTIFICATION
-
RTECS NUMBER :
-
UK7895000
-
CHEMICAL NAME :
-
Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-15-methyl-9-oxo-, (5Z,11-alpha,13E,15R)-
-
CAS REGISTRY NUMBER :
-
55028-70-1
-
LAST UPDATED :
-
199806
-
DATA ITEMS CITED :
-
7
-
MOLECULAR FORMULA :
-
C21-H34-O5
-
MOLECULAR WEIGHT :
-
366.55
-
WISWESSER LINE NOTATION :
-
L5VTJ B2U4VQ C1U1XQ5&1 DQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intramuscular
-
DOSE :
-
600 ng/kg
-
SEX/DURATION :
-
female 12 week(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Fertility - abortion
-
REFERENCE :
-
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 9,523,1974
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
DOSE :
-
2800 ug/kg
-
SEX/DURATION :
-
female 15-22 day(s) after conception lactating female 21 day(s) post-birth
-
TOXIC EFFECTS :
-
Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
-
REFERENCE :
-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 21,62A,1980
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
DOSE :
-
84 mg/kg
-
SEX/DURATION :
-
male 63 day(s) pre-mating female 14 day(s) pre-mating - 7 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)
-
REFERENCE :
-
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 16(Suppl 4),S949,1988
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
DOSE :
-
22 mg/kg
-
SEX/DURATION :
-
female 7-17 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Fertility - abortion Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Effects on Newborn - live birth index (measured after birth)
-
REFERENCE :
-
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 16(Suppl 4),S957,1988
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
DOSE :
-
1400 ug/kg
-
SEX/DURATION :
-
female 14 day(s) pre-mating
-
TOXIC EFFECTS :
-
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
-
REFERENCE :
-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 21,71A,1980
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
DOSE :
-
10400 ug/kg
-
SEX/DURATION :
-
female 17 ? after conception - 21 day(s) post-birth
-
TOXIC EFFECTS :
-
Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn - live birth index (measured after birth)
-
REFERENCE :
-
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 16(Suppl 4),S981,1988 *** REVIEWS *** TOXICOLOGY REVIEW AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920- Volume(issue)/page/year: 113,130,1972
|
