genkwadaphnin

Modify Date: 2024-01-05 14:26:57

genkwadaphnin structure	Common Name	genkwadaphnin
	CAS Number	55073-32-0	Molecular Weight	602.62800
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₄H₃₄O₁₀	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of genkwadaphnin

Genkwadaphnin is a daphnane diterpenoid, targeting of importin-β1 to reduce the nuclear accumulation of key CRPC drivers, and shut down their downstream oncogenic signaling. Genkwadaphnin shows potent anti-tumor activity and inhibits castration-resistant prostate cancer (CRPC) in vivo in mice[1].

Name	genkwadaphnin
Synonym	More Synonyms

Description	Genkwadaphnin is a daphnane diterpenoid, targeting of importin-β1 to reduce the nuclear accumulation of key CRPC drivers, and shut down their downstream oncogenic signaling. Genkwadaphnin shows potent anti-tumor activity and inhibits castration-resistant prostate cancer (CRPC) in vivo in mice[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	Importin-β1[1]
References	[1]. Huang JL, et al. Discovery of Highly Potent Daphnane Diterpenoids Uncovers Importin-β1 as a Druggable Vulnerability in Castration-Resistant Prostate Cancer. J Am Chem Soc. 2022 Sep 14.