Deferasirox (Fe3+ chelate)

Modify Date: 2024-01-03 01:48:22

Deferasirox (Fe3+ chelate) structure	Common Name	Deferasirox (Fe3+ chelate)
	CAS Number	554435-83-5	Molecular Weight	426.18300
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₁H₁₂FeN₃O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Deferasirox (Fe3+ chelate)

Deferasirox Fe3+ chelate is a rationally-designed oral iron chelator; its main use is to reduce chronic iron overload in patients who are receiving long-term blood transfusions for conditions such as beta-thalassemia and other chronic anemias.

Name	4-[3,5-bis(2-oxidophenyl)-1,2,4-triazol-1-yl]benzoate,iron(3+)
Synonym	More Synonyms

Description	Deferasirox Fe3+ chelate is a rationally-designed oral iron chelator; its main use is to reduce chronic iron overload in patients who are receiving long-term blood transfusions for conditions such as beta-thalassemia and other chronic anemias.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Others
In Vitro	Deferasirox is the first oral medication approved in the USA for this purpose. The half-life of deferasirox is between 8 and 16 hours allowing once a day dosing. Two molecules of deferasirox are capable of binding to 1 atom of iron which are subsequently eliminated by fecal excretion. Its low molecular weight and high lipophilicity allows the drug to be taken orally unlike desferoxamine which has to be administered by IV route (intravenous infusion). Together with deferiprone, deferasirox seems to be capable of removing iron from cells (cardiac myocytes and hepatocytes) as well as removing iron from the blood.
References	[1]. Yang LP, Keam SJ, Keating GM. Deferasirox : a review of its use in the management of transfusional chronic iron overload. Drugs. 2007;67(15):2211-30. [2]. Kontoghiorghes GJ. Introduction of higher doses of deferasirox: better efficacy but not effective iron removal from the heart and increased risks of serious toxicities. Expert Opin Drug Saf. 2010 Jul;9(4):633-41. [3]. Galanello R, Campus S, Origa R. Deferasirox: pharmacokinetics and clinical experience. Expert Opin Drug Metab Toxicol. 2012 Jan;8(1):123-34. [4]. Donnelly JP, Lahav M. Deferasirox as adjunctive therapy for mucormycosis. J Antimicrob Chemother. 2012 Mar;67(3):519-20. [5]. Lui GY, Obeidy P, Ford SJ et al. The Iron Chelator, Deferasirox, as a Novel Strategy for Cancer Treatment: Oral Activity Against Human Lung Tumor Xenografts and Molecular Mechanism of Action. Mol Pharmacol. 2012 Oct 16. [Epub ahead of print]

Molecular Formula	C₂₁H₁₂FeN₃O₄
Molecular Weight	426.18300
Exact Mass	426.01800
PSA	116.96000
LogP	3.24990

Deferasirox Fe3+ chelate

CS-1166

Deferasirox (Fe3+ chelate)

Deferasirox (Fe3+ chelate)

Use of Deferasirox (Fe3+ chelate)

Names

Deferasirox (Fe3+ chelate) Biological Activity

Chemical & Physical Properties

Synonyms