Cefazedone

Modify Date: 2024-01-08 14:09:54

Cefazedone structure	Common Name	Cefazedone
	CAS Number	56187-47-4	Molecular Weight	548.443
	Density	1.8±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₁₈H₁₅Cl₂N₅O₅S₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Cefazedone

Cefazedone (Refosporen) is a first-generation cephalosporin with activity against Gram-positive and Gram-negative bacteria, and it is effective in the treatment of infections caused by sensitive bacteria. Cefazedone is a time-dependent antibiotic, the time of concentration exceeds the minimum inhibitory concentration (MIC) is the key pharmacokinetic-pharmacodynamic (PK-PD) variable associated with the killing of pathogens[1].

Name	(6R,7R)-7-[[2-(3,5-dichloro-4-oxopyridin-1-yl)acetyl]amino]-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Synonym	More Synonyms

Description	Cefazedone (Refosporen) is a first-generation cephalosporin with activity against Gram-positive and Gram-negative bacteria, and it is effective in the treatment of infections caused by sensitive bacteria. Cefazedone is a time-dependent antibiotic, the time of concentration exceeds the minimum inhibitory concentration (MIC) is the key pharmacokinetic-pharmacodynamic (PK-PD) variable associated with the killing of pathogens[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
References	[1]. Gao L, et al. A Pharmacokinetic and Pharmacodynamic Study on Intravenous Cefazedone Sodium in Patients with Community-acquired Pneumonia. Chin Med J (Engl). 2015 May 5;128(9):1160-4.

Density	1.8±0.1 g/cm3
Molecular Formula	C₁₈H₁₅Cl₂N₅O₅S₃
Molecular Weight	548.443
Exact Mass	546.961243
PSA	213.33000
LogP	0.92
Index of Refraction	1.761

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XI0372700

CHEMICAL NAME :: 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((3,5-dichloro-4-oxo-1(4H)- pyridinyl)acetyl)amino)-3-(((5-methyl-1,3,4-thiadiazo l-2-yl)thio)methyl)-8 -oxo-, (6R-trans)-

CAS REGISTRY NUMBER :: 56187-47-4

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C18-H15-Cl2-N5-O5-S3

MOLECULAR WEIGHT :: 548.46

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 88 mg/kg/17W-I

TOXIC EFFECTS :: Blood - normocytic anemia Blood - thrombocytopenia

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 90,135,1987

3,5-Dichloro-4-...

CAS#:56187-37-2

7-TDA

CAS#:30246-33-4

Cefazedone

CAS#:56187-47-4

Literature: Arzneimittel-Forschung/Drug Research, , vol. 29, # 2 A p. 362 - 369

Precursor 2
CAS#:56187-37-2 3,5-Dichloro-4-... CAS#:30246-33-4 7-TDA
DownStream 0

Cefazedonum

Refosporen

Cefazedone [INN:BAN]

Cefazedonum [INN-Latin]

3-(5-Methyl-1,3,4-thiadiazolyl-2-mercaptomethyl)-7-(3,5-dichloro-4-pyridon-1-ylacetamido)-3-cephem-4-carboxylic Acid

(6R,7R)-7-{[(3,5-Dichloro-4-oxopyridin-1(4H)-yl)acetyl]amino}-3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Cefazedone

(6R,7R)-7-{[(3,5-Dichloro-4-oxo-1(4H)-pyridinyl)acetyl]amino}-3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

(6R)-7t-[2-(3,5-dichloro-4-oxo-4H-pyridin-1-yl)-acetylamino]-3-(5-methyl-[1,3,4]thiadiazol-2-ylsulfanylmethyl)-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[2-(3,5-dichloro-4-oxo-1(4H)-pyridinyl)acetyl]amino]-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-, (6R,7R)-

MFCD01682029

Cefazedona

Refosporene

Cefazedona [INN-Spanish]