56-Dihydrouridine

Modify Date: 2024-01-08 20:18:19

56-Dihydrouridine Structure
56-Dihydrouridine structure
Common Name 56-Dihydrouridine
CAS Number 5627-05-4 Molecular Weight 246.22
Density 1.614g/cm3 Boiling Point N/A
Molecular Formula C9H14N2O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 56-Dihydrouridine


5,6-Dihydrouridine is a modified base found in conserved positions in the D-loop of tRNA in Bacteria, Eukaryota, and some Archaea.

 Names

Name dihydrouridine
Synonym More Synonyms

 56-Dihydrouridine Biological Activity

Description 5,6-Dihydrouridine is a modified base found in conserved positions in the D-loop of tRNA in Bacteria, Eukaryota, and some Archaea.
Related Catalog
Target

Human Endogenous Metabolite

In Vitro 5,6-Dihydrouridine (Dihydrouridine) is one of the posttranscriptionally modified nucleosides. It is a product of the reduction of uridine (U), and can be further modified to 5-methyldihydrouridine (m5D). 5,6-Dihydrouridine is commonly present in the tRNA from Bacteria, Eukaryota, and some Archaea. It is identified in six positions in the “D-loop” of the tRNA (16, 17, 20a, 20b) and in position 47 in the variable loop[1].
References

[1]. Kasprzak JM, et al. Molecular evolution of dihydrouridine synthases. BMC Bioinformatics. 2012 Jun 28;13:153.

 Chemical & Physical Properties

Density 1.614g/cm3
Molecular Formula C9H14N2O6
Molecular Weight 246.22
PSA 122.49000
Storage condition 2-8℃

 Synthetic Route

~96%

56-Dihydrouridine Structure

56-Dihydrouridine

CAS#:5627-05-4

Literature: Flockerzi, Dieter; Silber, Gunter; Charubala, Ramamurthy; Schlosser, Wilhelm; Varma, Rajendra Singh; et al. Liebigs Annalen der Chemie, 1981 , # 9 p. 1568 - 1585

~75%

56-Dihydrouridine Structure

56-Dihydrouridine

CAS#:5627-05-4

Literature: Johnson II, David C.; Widlanski, Theodore S. Organic Letters, 2004 , vol. 6, # 25 p. 4643 - 4646

~%

56-Dihydrouridine Structure

56-Dihydrouridine

CAS#:5627-05-4

Literature: Johnson II, David C.; Widlanski, Theodore S. Organic Letters, 2004 , vol. 6, # 25 p. 4643 - 4646

~%

56-Dihydrouridine Structure

56-Dihydrouridine

CAS#:5627-05-4

Literature: Johnson II, David C.; Widlanski, Theodore S. Organic Letters, 2004 , vol. 6, # 25 p. 4643 - 4646

~%

56-Dihydrouridine Structure

56-Dihydrouridine

CAS#:5627-05-4

Literature: Johnson II, David C.; Widlanski, Theodore S. Organic Letters, 2004 , vol. 6, # 25 p. 4643 - 4646

 Synonyms

3,4-Dihydrouridine
5,6-Dihydrouridin
Uridine,5,6-dihydro
Dihydrouridine
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3-diazinane-2,4-dione