Isochlorogenic acid C(4,5)

Modify Date: 2024-01-03 11:53:29

Isochlorogenic acid C(4,5) structure	Common Name	Isochlorogenic acid C(4,5)
	CAS Number	57378-72-0	Molecular Weight	516.451
	Density	1.6±0.1 g/cm3	Boiling Point	810.8±65.0 °C at 760 mmHg
	Molecular Formula	C₂₅H₂₄O₁₂	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	274.9±27.8 °C

Use of Isochlorogenic acid C(4,5)

4,5-Dicaffeoylquinic acid ( Isochlorogenic acid C) possesses potent hepatoprotective and anti-HBV effects.IC50 value:Target: Anti-hepatitis natural produce.In vitro: To study anti-hepatitis effect of isochlorogenic acid C, anti-apoptotic and anti-injury properties of test compound were evaluated. The results showed that test compound at concentrations of 10 to 100 μg/ml significantly reduced the caspase-3 and transformed growth factor β1 (TGFβ1) levels of the D-GalN-challenged hepatocytes. Also, test compound improved markedly cell viability of the D-GalN-injured hepatocytes and produced a maximum protection rate of 47.28% at a concentration of 100 μg/ml. Furthermore, test compound significantly inhibited productions of HBsAg and HBeAg. Its maximum inhibitory rates on the HBsAg and HBeAg expressions were 86.93 and 59.79%, respectively. In addition, test compound significantly induced the HO-1 expression of HepG2.2.15 cells [1]. In vivo:

Name	(1R,3R,4S,5R)-1,5-Dihydroxy-3,4-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-1-cyclohexanecarboxylic acid
Synonym	More Synonyms

Description	4,5-Dicaffeoylquinic acid ( Isochlorogenic acid C) possesses potent hepatoprotective and anti-HBV effects.IC50 value:Target: Anti-hepatitis natural produce.In vitro: To study anti-hepatitis effect of isochlorogenic acid C, anti-apoptotic and anti-injury properties of test compound were evaluated. The results showed that test compound at concentrations of 10 to 100 μg/ml significantly reduced the caspase-3 and transformed growth factor β1 (TGFβ1) levels of the D-GalN-challenged hepatocytes. Also, test compound improved markedly cell viability of the D-GalN-injured hepatocytes and produced a maximum protection rate of 47.28% at a concentration of 100 μg/ml. Furthermore, test compound significantly inhibited productions of HBsAg and HBeAg. Its maximum inhibitory rates on the HBsAg and HBeAg expressions were 86.93 and 59.79%, respectively. In addition, test compound significantly induced the HO-1 expression of HepG2.2.15 cells [1]. In vivo:
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Infection Natural Products >> Phenylpropanoids
References	[1]. Shaoqing Hu, et al.Evaluation of anti-apoptotic, anti-injury and antihepatitis B virus effects of isochlorogenic acid C in vitro. Journal of Medicinal Plants Research Vol. 6(16), pp. 3199-3206 30 April, 2012

Density	1.6±0.1 g/cm3
Boiling Point	810.8±65.0 °C at 760 mmHg
Molecular Formula	C₂₅H₂₄O₁₂
Molecular Weight	516.451
Flash Point	274.9±27.8 °C
Exact Mass	516.126770
PSA	211.28000
LogP	0.89
Vapour Pressure	0.0±3.0 mmHg at 25°C
Index of Refraction	1.719
Storage condition	-20°C

Isochlorogenic acid C(4,5) MSDS(Chinese)

RIDADR	NONH for all modes of transport

4,5-di-O-trans-caffeoyl-D-quinic acid

(1R,3R,4S,5R)-3,4-Bis{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}-1,5-dihydroxycyclohexanecarboxylic acid

4,5-Dinitrophenanthren

Cyclohexanecarboxylic acid, 3,4-bis[[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-1,5-dihydroxy-, (1R,3R,4S,5R)-

(1R,3R,4S,5R)-3,4-Bis{[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoyl]oxy}-1,5-dihydroxycyclohexanecarboxylic acid

Isochlorogenic acid C

(1S,3R,4S,5R)-4-((E)-4-(3,4-Dihydroxyphenyl)-2-oxobut-3-en-1-yl)-3-(((E)-3-(3,4-dihydroxyphenyl)acryloyl)oxy)-5-hydroxy-1-methylcyclohexanecarboxylic acid

N1748

4,5-di-O-caffeoylquinic acid

4,5-di-O-trans-caffeoylquininc acid

Phenanthrene,4,5-dinitro

4,5-Dicaffeoylquinic acid