mannomustine

Modify Date: 2024-01-16 01:05:37

mannomustine Structure
mannomustine structure
 Common Name mannomustine
CAS Number 576-68-1 Molecular Weight 305.19900
Density 1.353g/cm3 Boiling Point 541.9ºC at 760 mmHg
Molecular Formula C10H22Cl2N2O4 Melting Point 278°C (rough estimate)
MSDS N/A Flash Point 281.5ºC

 Names

Name (2R,3R,4R,5R)-1,6-bis(2-chloroethylamino)hexane-2,3,4,5-tetrol
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.353g/cm3
Boiling Point 541.9ºC at 760 mmHg
Melting Point 278°C (rough estimate)
Molecular Formula C10H22Cl2N2O4
Molecular Weight 305.19900
Flash Point 281.5ºC
Exact Mass 304.09600
PSA 104.98000
Index of Refraction 1.544

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OP2100000
CHEMICAL NAME :
Mannitol, 1,6-bis((2-chloroethyl)amino)-1,6-dideoxy-, D-,
CAS REGISTRY NUMBER :
576-68-1
LAST UPDATED :
199707
DATA ITEMS CITED :
13
MOLECULAR FORMULA :
C10-H22-Cl2-N2-O4
MOLECULAR WEIGHT :
305.24
WISWESSER LINE NOTATION :
G2M1YQYQYQYQ1M2G -D

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
56 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
56 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
90 mg/kg
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
90 mg/kg
TOXIC EFFECTS :
Tumorigenic - protects against induction of experimental tumors
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Blood - changes in spleen Tumorigenic - protects against induction of experimental tumors
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Blood - leukopenia
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
20 mg/kg
TOXIC EFFECTS :
Blood - changes in spleen Tumorigenic - protects against induction of experimental tumors
TYPE OF TEST :
Cytogenetic analysis
TYPE OF TEST :
Sister chromatid exchange

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Cells - not otherwise specified
DOSE/DURATION :
2900 nmol/L
REFERENCE :
SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.2- 1966- Volume(issue)/page/year: 18,210,1982

 Synthetic Route

1,6-bis-aziridin-1-yl-O3,O4-isopropylidene-1,6-dideoxy-D-mannitol structure

1,6-bis-aziridi...

CAS#:16658-08-5

~%

mannomustine Structure

mannomustine

CAS#:576-68-1

Literature: Vargha et al. Journal of the Chemical Society, 1957 , p. 805,809
1,6-bis-(2-hydroxy-ethylamino)-O2,O4,O3,O5-dimethanediyl-1,6-dideoxy-L-iditol structure

1,6-bis-(2-hydr...

CAS#:108991-70-4

~%

mannomustine Structure

mannomustine

CAS#:576-68-1

Literature: Vargha et al. Journal of the Chemical Society, 1957 , p. 805,809
2,7-bis[(4-methylphenyl)sulfonyloxymethyl]-3,5,8,10-tetraoxabicyclo[4.4.0]decane structure

2,7-bis[(4-meth...

CAS#:7465-84-1

~%

mannomustine Structure

mannomustine

CAS#:576-68-1

Literature: Vargha et al. Journal of the Chemical Society, 1957 , p. 805,809

 Synonyms

Mannit-lost [German]
Mannomustin
Mannitol nitrogen mustard
Manomustina [INN-Spanish]
Mannomustine [INN:BAN:DCF]
Mannit-mustard [German]
Mannit-Lost
Mannomustinum [INN-Latin]
1,6-Bis-<(2-chlorethyl)-amino>-1,6-dideoxy-D-mannitol
1,6-Bis-(2-chlor-aethylamino)-1,6-didesoxy-D-mannit
BCM (cytostatic)
mannomustine
1,6-bis-(2-chloro-ethylamino)-1,6-dideoxy-D-mannitol
1,6-Bis-<2-chlor-ethylamino>-1,6-didesoxy-D-mannit
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