RNA Polymerase III Inhibitor
Modify Date: 2026-07-17 08:27:23
RNA Polymerase III Inhibitor structure
|
Common Name | RNA Polymerase III Inhibitor | ||
|---|---|---|---|---|
| CAS Number | 577784-91-9 | Molecular Weight | 452.377 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 632.3±65.0 °C at 760 mmHg | |
| Molecular Formula | C19H15Cl2N3O2S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 336.2±34.3 °C | |
Use of RNA Polymerase III InhibitorML-60218 is a broad-spectrum RNA pol III inhibitor, with IC50s of 32 and 27 μM for Saccharomyces cerevisiae and human. ML-60218 disrupts already assembled viroplasms and to hamper the formation of new ones without the need for de novo transcription of cellular RNAs[1][2]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | 2-chloro-N-[5-(5-chloro-3-methyl-1-benzothiophen-2-yl)-2-methylpyrazol-3-yl]benzenesulfonamide |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | ML-60218 is a broad-spectrum RNA pol III inhibitor, with IC50s of 32 and 27 μM for Saccharomyces cerevisiae and human. ML-60218 disrupts already assembled viroplasms and to hamper the formation of new ones without the need for de novo transcription of cellular RNAs[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | Combination of SAHA and ML-60218 produces enhanced suppression of proliferation in human pancreatic adenocarcinoma by impairing cell cycle progression and inducing apoptosis. ML-60218 reverses SAHA-stimulated tRNA expression in PANC-1 and BxPC-3 cells. ML-60218 enhances the ability of HDAC inhibitors to induce apoptosis and cell cycle arrest[2]. In in vitro transcription assays with purified double-layered particles (DLPs), ML-60218 shows dose-dependent inhibitory activity, indicating the viral nature of its target. ML-60218 is found to interfere with the formation of higher-order structures of VP6, the protein forming the DLP outer layer, without compromising its ability to trimerize. Electron microscopy of ML-60218-treated DLPs shows dose-dependent structural damage. ML-60218-mediated (10 μM ) viroplasm disruption causes NSP5 dephosphorylation[3]. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 632.3±65.0 °C at 760 mmHg |
| Molecular Formula | C19H15Cl2N3O2S2 |
| Molecular Weight | 452.377 |
| Flash Point | 336.2±34.3 °C |
| Exact Mass | 450.998260 |
| PSA | 100.61000 |
| LogP | 6.83 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.715 |
| InChIKey | BVBDTTLISMIOJY-UHFFFAOYSA-N |
| SMILES | Cc1c(-c2cc(NS(=O)(=O)c3ccccc3Cl)n(C)n2)sc2ccc(Cl)cc12 |
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| RNA Polymerase III Inhibitor |
| 2-Chloro-N-[3-(5-chloro-3-methyl-1-benzothiophen-2-yl)-1-methyl-1H-pyrazol-5-yl]benzenesulfonamide |
| N1-[3-(5-chloro-3-methylbenzo[b]thiophen-2-yl)-1-methyl-1H-pyrazol-5-yl]-2-chlorobenzene-1-sulfonamide |
| ML-60218 |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the CAS number of 2-chloro-N-[5-(5-chloro-3-methyl-1-benzothiophen-2-yl)-2-methylpyrazol-3-yl]benzenesulfonamide? |
| A: CAS number of 2-chloro-N-[5-(5-chloro-3-methyl-1-benzothiophen-2-yl)-2-methylpyrazol-3-yl]benzenesulfonamide is 577784-91-9. |
| Q: What is the InChIKey of 2-chloro-N-[5-(5-chloro-3-methyl-1-benzothiophen-2-yl)-2-methylpyrazol-3-yl]benzenesulfonamide? |
| A: InChIKey of 2-chloro-N-[5-(5-chloro-3-methyl-1-benzothiophen-2-yl)-2-methylpyrazol-3-yl]benzenesulfonamide is BVBDTTLISMIOJY-UHFFFAOYSA-N. |
| Q: What is the Chinese name of 577784-91-9? |
| A: Chinese name of 577784-91-9 is ML-60218. |
| Q: What is the boiling point of 2-chloro-N-[5-(5-chloro-3-methyl-1-benzothiophen-2-yl)-2-methylpyrazol-3-yl]benzenesulfonamide? |
| A: Boiling point of 2-chloro-N-[5-(5-chloro-3-methyl-1-benzothiophen-2-yl)-2-methylpyrazol-3-yl]benzenesulfonamide is 632.3±65.0 °C at 760 mmHg. |
| Q: What are the uses of 2-chloro-N-[5-(5-chloro-3-methyl-1-benzothiophen-2-yl)-2-methylpyrazol-3-yl]benzenesulfonamide? |
| A: Main uses of 2-chloro-N-[5-(5-chloro-3-methyl-1-benzothiophen-2-yl)-2-methylpyrazol-3-yl]benzenesulfonamide: ML-60218 is a broad-spectrum RNA pol III inhibitor, with IC50s of 32 and 27 μM for Saccharomyces cerevisiae and human. ML-60218 disrupts already assembled viroplasms and to hamper the formation of new ones without the need for de novo transcription of cellular RNAs[1][2]. |
| Q: What is the molecular formula of 2-chloro-N-[5-(5-chloro-3-methyl-1-benzothiophen-2-yl)-2-methylpyrazol-3-yl]benzenesulfonamide? |
| A: Molecular formula of 2-chloro-N-[5-(5-chloro-3-methyl-1-benzothiophen-2-yl)-2-methylpyrazol-3-yl]benzenesulfonamide is C19H15Cl2N3O2S2. |
| Q: What English synonyms does 2-chloro-N-[5-(5-chloro-3-methyl-1-benzothiophen-2-yl)-2-methylpyrazol-3-yl]benzenesulfonamide have? |
| A: English synonyms of 2-chloro-N-[5-(5-chloro-3-methyl-1-benzothiophen-2-yl)-2-methylpyrazol-3-yl]benzenesulfonamide: RNA Polymerase III Inhibitor, 2-Chloro-N-[3-(5-chloro-3-methyl-1-benzothiophen-2-yl)-1-methyl-1H-pyrazol-5-yl]benzenesulfonamide, N1-[3-(5-chloro-3-methylbenzo[b]thiophen-2-yl)-1-methyl-1H-pyrazol-5-yl]-2-chlorobenzene-1-sulfonamide, ML-60218. |
| Q: What is the SMILES notation of 2-chloro-N-[5-(5-chloro-3-methyl-1-benzothiophen-2-yl)-2-methylpyrazol-3-yl]benzenesulfonamide? |
| A: SMILES notation of 2-chloro-N-[5-(5-chloro-3-methyl-1-benzothiophen-2-yl)-2-methylpyrazol-3-yl]benzenesulfonamide is Cc1c(-c2cc(NS(=O)(=O)c3ccccc3Cl)n(C)n2)sc2ccc(Cl)cc12. |
| Q: What is the LogP of 2-chloro-N-[5-(5-chloro-3-methyl-1-benzothiophen-2-yl)-2-methylpyrazol-3-yl]benzenesulfonamide? |
| A: LogP of 2-chloro-N-[5-(5-chloro-3-methyl-1-benzothiophen-2-yl)-2-methylpyrazol-3-yl]benzenesulfonamide is 6.83. |
| Q: What is the English name of 2-chloro-N-[5-(5-chloro-3-methyl-1-benzothiophen-2-yl)-2-methylpyrazol-3-yl]benzenesulfonamide? |
| A: The English name of 2-chloro-N-[5-(5-chloro-3-methyl-1-benzothiophen-2-yl)-2-methylpyrazol-3-yl]benzenesulfonamide is 2-chloro-N-[5-(5-chloro-3-methyl-1-benzothiophen-2-yl)-2-methylpyrazol-3-yl]benzenesulfonamide. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |