Alanosine

Modify Date: 2024-01-08 17:35:08

Alanosine Structure
Alanosine structure
 Common Name Alanosine
CAS Number 5854-93-3 Molecular Weight 149.105
Density 1.8±0.1 g/cm3 Boiling Point 366.9±52.0 °C at 760 mmHg
Molecular Formula C3H7N3O4 Melting Point 190ºC (dec.)
MSDS N/A Flash Point 175.7±30.7 °C

 Use of Alanosine


L-Alanosine (NSC-153353), an antibiotic from Streptomyces alanosinicus, has antineoplastic activity. L-Alanosine (NSC-153353) inhibits adenylosuccinate synthetase, which converts inosine monophospate (IMP) into adenylosuccinate. L-Alanosine (NSC-153353) blocks the common de novo purine biosynthesis pathway and, thereby, inhibits tumor cells with MTAP deficiency[1][2][3].

 Names

Name L-Alanine,3-(hydroxynitrosoamino)
Synonym More Synonyms

 Alanosine Biological Activity

Description L-Alanosine (NSC-153353), an antibiotic from Streptomyces alanosinicus, has antineoplastic activity. L-Alanosine (NSC-153353) inhibits adenylosuccinate synthetase, which converts inosine monophospate (IMP) into adenylosuccinate. L-Alanosine (NSC-153353) blocks the common de novo purine biosynthesis pathway and, thereby, inhibits tumor cells with MTAP deficiency[1][2][3].
Related Catalog
References

[1]. Efferth T, et al. Identification of gene expression profiles predicting tumor cell response to L-alanosine. Biochem Pharmacol. 2003 Aug 15;66(4):613-21.

[2]. Chitnis MP, et al. Antitumor effect of L-alanosine (NSC 153553) on sensitive and resistant sublines of murine leukemias. Tumori. 1984 Aug 31;70(4):317-20.

[3]. Tyagi AK, et al. Identification of the antimetabolite of L-alanosine, L-alanosyl-5-amino-4-imidazolecarboxylic acid ribonucleotide, in tumors and assessment of its inhibition of adenylosuccinate synthetase. Cancer Res. 1980 Dec;40(12):4390-7.

 Chemical & Physical Properties

Density 1.8±0.1 g/cm3
Boiling Point 366.9±52.0 °C at 760 mmHg
Melting Point 190ºC (dec.)
Molecular Formula C3H7N3O4
Molecular Weight 149.105
Flash Point 175.7±30.7 °C
Exact Mass 149.043655
PSA 116.22000
LogP -0.56
Vapour Pressure 0.0±1.9 mmHg at 25°C
Index of Refraction 1.616

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UE6490000
CHEMICAL NAME :
Propionic acid, 2-amino-3-(hydroxynitrosamino)-, (L)-
CAS REGISTRY NUMBER :
5854-93-3
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C3-H7-N3-O4
MOLECULAR WEIGHT :
149.13
WISWESSER LINE NOTATION :
QVYZ1NQNO -L

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3676490
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
845 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3676490

 Precursor & DownStream

Precursor  2

DownStream  0

 Synonyms

SDX-102
L-Alanine, 3-(hydroxynitrosoamino)-
L-2-Amino-3-[(N-nitroso)hydroxylamino]propionic acid
alanosine
L-2-Amino-3-(hydroxynitrosoamino)propanoic Acid
3-[Hydroxy(nitroso)amino]-L-alanine
SDX 102
L-alanosine
L-Alanine, 3- (hydroxynitrosoamino)-
Top Suppliers:I want be here

Get all suppliers and price by the below link:

Alanosine suppliers

Alanosine price

Related Compounds: More...
DL-Alanosine
5854-95-5
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1158522-08-7
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
940364-43-2
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
134104-43-1
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
131615-57-1
(4-Methyl-tetrahydro-furan-2-yl)-methanol
6906-52-1
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
930439-75-1
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
1018584-77-4
tert-Butyl-DL-alanine
1375289-11-4
4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide
849349-65-1
N-[3-(Aminooxy)propyl]-N-butyl-1-butanamine
127437-46-1
Chemsrc provides Alanosine(CAS#:5854-93-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Alanosine are included as well.>> amp version: Alanosine

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved