Biotin-PEG2-NHS ester

Modify Date: 2025-08-25 16:33:58

Biotin-PEG2-NHS ester Structure
Biotin-PEG2-NHS ester structure
Common Name Biotin-PEG2-NHS ester
CAS Number 596820-83-6 Molecular Weight 500.56578
Density N/A Boiling Point N/A
Molecular Formula C21H32N4O8S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Biotin-PEG2-NHS ester


Biotin-PEG2-NHS ester is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 9-biotinlaMino-4,7-dioxanonanoic acid N-hydroxysucciniMidyl ester

 Biotin-PEG2-NHS ester Biological Activity

Description Biotin-PEG2-NHS ester is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521.

 Chemical & Physical Properties

Molecular Formula C21H32N4O8S
Molecular Weight 500.56578
InChIKey UCJSJBIJPAZUGU-AVYPCKFXSA-N
SMILES O=C(CCCCC1SCC2NC(=O)NC21)NCCOCCOCCC(=O)ON1C(=O)CCC1=O
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