Exisulind
Exisulind structure
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Common Name | Exisulind | ||
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| CAS Number | 59864-04-9 | Molecular Weight | 372.41 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 601.9±55.0 °C at 760 mmHg | |
| Molecular Formula | C20H17FO4S | Melting Point | N/A | |
| MSDS | USA | Flash Point | 317.8±31.5 °C | |
Use of ExisulindExisulind is an inactive metabolite of the nonsteroidal, anti-inflammatory agent sulindac[1]. Exisulind inhibits aldose reductase with an IC50 of 367 nM in vitro and may contribute to the beneficial pharmacological effects of sulindac on type 2 diabetic complications[2]. |
| Name | Sulindac sulfone |
|---|---|
| Synonym | More Synonyms |
| Description | Exisulind is an inactive metabolite of the nonsteroidal, anti-inflammatory agent sulindac[1]. Exisulind inhibits aldose reductase with an IC50 of 367 nM in vitro and may contribute to the beneficial pharmacological effects of sulindac on type 2 diabetic complications[2]. |
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| Related Catalog | |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 601.9±55.0 °C at 760 mmHg |
| Molecular Formula | C20H17FO4S |
| Molecular Weight | 372.41 |
| Flash Point | 317.8±31.5 °C |
| Exact Mass | 372.083160 |
| PSA | 79.82000 |
| LogP | 3.54 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.620 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
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Exisulind: Aptosyn, FGN 1, Prevatac, sulindac sulfone.
Drugs R. D. 5(4) , 220-6, (2004) Exisulind [Aptosyn trade mark, FGN 1 trade mark, Prevatac trade mark, sulindac sulfone], the sulfone derivative of sulindac, is the lead compound in a series of selective apoptotic antineoplastic drug... |
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Sulindac sulfide, but not sulindac sulfone, inhibits colorectal cancer growth.
Neoplasia 1(2) , 170-6, (1999) Sulindac sulfide, a metabolite of the nonsteroidal antiinflammatory drug (NSAID) sulindac sulfoxide, is effective at reducing tumor burden in both familial adenomatous polyposis patients and in animal... |
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Sulindac sulfone inhibits K-ras-dependent cyclooxygenase-2 expression in human colon cancer cells.
Cancer Res. 60(23) , 6607-10, (2000) Both the sulfide and sulfone metabolites of sulindac, a nonsteroidal anti-inflammatory drug, display anticarcinogenic effects in experimental models. Sulindac sulfide inhibits cyclooxygenase (COX) enz... |
| MFCD01317811 |
| 2-[6-fluoro-2-methyl-3-[(4-methylsulfonylphenyl)methylidene]inden-1-yl]acetic acid |
| Exisulind |
| 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-[[4-(methylsulfonyl)phenyl]methylene]-, (1Z)- |
| Sulindac Sulfone |
| {(1Z)-5-Fluoro-2-methyl-1-[4-(methylsulfonyl)benzylidene]-1H-inden-3-yl}acetic acid |