Dihydro Cyclosporin A

Modify Date: 2024-01-20 12:01:16

Dihydro Cyclosporin A Structure
Dihydro Cyclosporin A structure
Common Name Dihydro Cyclosporin A
CAS Number 59865-15-5 Molecular Weight 1204.627
Density 1.0±0.1 g/cm3 Boiling Point 1285.3±65.0 °C at 760 mmHg
Molecular Formula C62H113N11O12 Melting Point 120-125ºC
MSDS N/A Flash Point 731.1±34.3 °C

 Use of Dihydro Cyclosporin A


Dihydrocyclosporin A is a derivative of Cyclosporine A (HY-B0579). Dihydrocyclosporin A significantly inhibites promastigotes and intracellular amastigotes. Dihydrocyclosporin A is highly cytotoxic[1].

 Names

Name Dihydro Cyclosporin A
Synonym More Synonyms

 Dihydro Cyclosporin A Biological Activity

Description Dihydrocyclosporin A is a derivative of Cyclosporine A (HY-B0579). Dihydrocyclosporin A significantly inhibites promastigotes and intracellular amastigotes. Dihydrocyclosporin A is highly cytotoxic[1].
Related Catalog
References

[1]. Zheng ZW, et al. Evaluation of in vitro antileishmanial efficacy of cyclosporin A and its non-immunosuppressive derivative, dihydrocyclosporin A. Parasit Vectors. 2020 Feb 21;13(1):94.  

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 1285.3±65.0 °C at 760 mmHg
Melting Point 120-125ºC
Molecular Formula C62H113N11O12
Molecular Weight 1204.627
Flash Point 731.1±34.3 °C
Exact Mass 1203.857056
PSA 278.80000
LogP 3.67
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.465
Storage condition -20°C

 Precursor & DownStream

Precursor  3

DownStream  0

 Synonyms

6-[(2S,3R,4R)-3-Hydroxy-4-Methyl-2-(MethylaMino)octanoic acid]cyclosporin A
<DH-MeBmt>cyclosporin
dihydro-CSA
DIHYDROCYCLOSPORIN A
Dihydrocyclosporin
(3S,6S,9S,12R,15S,18S,21S,24S,30S)-30-Ethyl-33-[(1R,2R)-1-hydroxy-2-methylhexyl]-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
(3R,4R)-3-Hydroxy-N-methyl-5-propylcyclo(L-Leu-L-Abu-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-)
(3R,4R)-3-Hydroxy-4,N-dimethyl-5-propylcyclo[L-Nva-L-Abu-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-]
1,4,7,10,13,16,19,22,25,28,31-Undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone, 30-ethyl-33-[(1R,2R)-1-hydroxy-2-methylhexyl]-1,4,7,10,12,15,19,25,28-nonamethyl-3,21-bis(1-methylethyl)-6,9,18,24-tetrakis(2-methylpropyl)-, (3S,6S,9S,12R,15S,18S,21S,24S,30S)-
Cyclosporin Impurity 10
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