Medicagenic acid

Modify Date: 2025-08-25 16:35:47

Medicagenic acid Structure
Medicagenic acid structure
Common Name Medicagenic acid
CAS Number 599-07-5 Molecular Weight 502.68300
Density 1.23g/cm3 Boiling Point 635.9ºC at 760 mmHg
Molecular Formula C30H46O6 Melting Point 380-382ºC (dec.)
MSDS N/A Flash Point 352.4ºC

 Use of Medicagenic acid


Medicagenic acid (Castanogenin) is isolated from the roots of Herniaria glabra L, exhibits potent fungistatic effects against several plant pathogens and human dermatophytes[1]. Medicagenic acid (Castanogenin) has low enzyme inhibitory activities, the target enzymes are xanthine oxidase, collagenase, elastase, tyrosinase, ChE[2].

 Names

Name (2S,3R,4S,4aR,6aR,6bS,8aS,12aS,14aR,14bR)-2,3-dihydroxy-4,6a,6b,11,11,14b-hexamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicene-4,8a-dicarboxylic acid
Synonym More Synonyms

 Medicagenic acid Biological Activity

Description Medicagenic acid (Castanogenin) is isolated from the roots of Herniaria glabra L, exhibits potent fungistatic effects against several plant pathogens and human dermatophytes[1]. Medicagenic acid (Castanogenin) has low enzyme inhibitory activities, the target enzymes are xanthine oxidase, collagenase, elastase, tyrosinase, ChE[2].
Related Catalog
References

[1]. Zehavi U, et al. Saponins as antimycotic agents: glycosides of medicagenic acid. Adv Exp Med Biol. 1996;404:535-46.

[2]. https://www.ncbi.nlm.nih.gov/pubmed/31627115

 Chemical & Physical Properties

Density 1.23g/cm3
Boiling Point 635.9ºC at 760 mmHg
Melting Point 380-382ºC (dec.)
Molecular Formula C30H46O6
Molecular Weight 502.68300
Flash Point 352.4ºC
Exact Mass 502.32900
PSA 115.06000
LogP 5.26910
Index of Refraction 1.587
InChIKey IDGXIXSKISLYAC-WNTKNEGGSA-N
SMILES CC1(C)CCC2(C(=O)O)CCC3(C)C(=CCC4C5(C)CC(O)C(O)C(C)(C(=O)O)C5CCC43C)C2C1

 Medicagenic acidBioassay

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Name: Binding affinity to photoactivated rhodopsin in bovine retinal rod outer-segment memb...
Source: ChEMBL
Target: Rhodopsin
External Id: CHEMBL977315
Name: Neuroprotective activity against H2O2-induced cell death in human SH-SY5Y cells asses...
Source: ChEMBL
Target: SH-SY5Y
External Id: CHEMBL4611637
Name: Inhibition of human recombinant N-terminal His-tagged 15-LOX2 expressed in Escherichi...
Source: ChEMBL
Target: Polyunsaturated fatty acid lipoxygenase ALOX15B
External Id: CHEMBL4417326
Name: HIV Enzyme Data
Source: NIAID
Target: N/A
External Id: HIV Enzyme Data
Name: Inhibition of human recombinant N-terminal His-tagged 15-LOX2 expressed in Escherichi...
Source: ChEMBL
Target: Polyunsaturated fatty acid lipoxygenase ALOX15B
External Id: CHEMBL4417327
Name: Inhibition of ovine recombinant COX1 assessed as decrease in formation of PGE2 using ...
Source: ChEMBL
Target: Prostaglandin G/H synthase 1
External Id: CHEMBL4417328
Name: Inhibition of ovine recombinant COX1 assessed as residual activity at 42 uM using ara...
Source: ChEMBL
Target: Prostaglandin G/H synthase 1
External Id: CHEMBL4417329
Name: Inhibition of human recombinant COX2 expressed in baculovirus infected sf21 cells ass...
Source: ChEMBL
Target: Prostaglandin G/H synthase 2
External Id: CHEMBL4417330
Name: Inhibition of human recombinant COX2 expressed in baculovirus infected sf21 cells ass...
Source: ChEMBL
Target: Prostaglandin G/H synthase 2
External Id: CHEMBL4417331
Name: HIV Cellular Data
Source: NIAID
Target: N/A
External Id: HIV Cellular Data
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 Synonyms

Medicagenic acid
medicagensaeure
Castanogenin
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