Clorsulon

Modify Date: 2024-01-02 18:36:37

Clorsulon structure	Common Name	Clorsulon
	CAS Number	60200-06-8	Molecular Weight	380.656
	Density	1.8±0.1 g/cm3	Boiling Point	651.7±65.0 °C at 760 mmHg
	Molecular Formula	C₈H₈Cl₃N₃O₄S₂	Melting Point	194-203°C
	MSDS	Chinese USA	Flash Point	348.0±34.3 °C

Use of Clorsulon

Clorsulon is used in the treatment of Fasciola hepatica infections in calves and sheep.Target: AntiparasiticClorsulon is a competitive inhibitor of both 3-phosphoglycorate and ATP and had a Ki of 0.29 mM, inhibits glucose utilization and acetate and propionate formation by mature Fasciola hepatica in vitro. [1] Clorsulon (a single dose of 15 mg/kg) is effective in removing over 90% of immature Fasciola hepatica from sheep (6 weeks after infection) and calves (8 weeks after infection). A 2.5 mg/kg dose removed over 90% of mature (16 weeks old) liver fluke from sheep [1]. Clorsulon causes severe disruption to the tegument and gut of Fasciola hepatica after in vivo incubation [2].

Name	4-amino-6-(1,2,2-trichloroethenyl)benzene-1,3-disulfonamide
Synonym	More Synonyms

Description	Clorsulon is used in the treatment of Fasciola hepatica infections in calves and sheep.Target: AntiparasiticClorsulon is a competitive inhibitor of both 3-phosphoglycorate and ATP and had a Ki of 0.29 mM, inhibits glucose utilization and acetate and propionate formation by mature Fasciola hepatica in vitro. [1] Clorsulon (a single dose of 15 mg/kg) is effective in removing over 90% of immature Fasciola hepatica from sheep (6 weeks after infection) and calves (8 weeks after infection). A 2.5 mg/kg dose removed over 90% of mature (16 weeks old) liver fluke from sheep [1]. Clorsulon causes severe disruption to the tegument and gut of Fasciola hepatica after in vivo incubation [2].
Related Catalog	Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Infection
References	[1]. Mrozik, H., et al., 4-amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide, a new, potent fasciolicide. J Med Chem, 1977. 20(9): p. 1225-7. [2]. Meaney, M., et al., Transmission electron microscope study of the ultrastructural changes induced in the tegument and gut of Fasciola hepatica following in vivo drug treatment with clorsulon. Parasitol Res, 2004. 92(3): p. 232-41.

Description

Related Catalog

Signaling Pathways >> Anti-infection >> Parasite

Research Areas >> Infection

References

[1]. Mrozik, H., et al., 4-amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide, a new, potent fasciolicide. J Med Chem, 1977. 20(9): p. 1225-7.

[2]. Meaney, M., et al., Transmission electron microscope study of the ultrastructural changes induced in the tegument and gut of Fasciola hepatica following in vivo drug treatment with clorsulon. Parasitol Res, 2004. 92(3): p. 232-41.

Density	1.8±0.1 g/cm3
Boiling Point	651.7±65.0 °C at 760 mmHg
Melting Point	194-203°C
Molecular Formula	C₈H₈Cl₃N₃O₄S₂
Molecular Weight	380.656
Flash Point	348.0±34.3 °C
Exact Mass	378.902191
PSA	163.10000
LogP	1.04
Vapour Pressure	0.0±2.0 mmHg at 25°C
Index of Refraction	1.665
Storage condition	0-6°C

Clorsulon MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CZ9090000

CHEMICAL NAME :: 1,3-Benzenedisulfonamide, 4-amino-6-(trichloroethenyl)-

CAS REGISTRY NUMBER :: 60200-06-8

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C8-H8-Cl3-N3-O4-S2

MOLECULAR WEIGHT :: 380.66

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BVJOA9 British Veterinary Journal. (Bailliere Tindall, 33 The Avenue, Eastbourne BN21 3UN, UK) V.105- 1949- Volume(issue)/page/year: 133,211,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BVJOA9 British Veterinary Journal. (Bailliere Tindall, 33 The Avenue, Eastbourne BN21 3UN, UK) V.105- 1949- Volume(issue)/page/year: 133,211,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 761 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BVJOA9 British Veterinary Journal. (Bailliere Tindall, 33 The Avenue, Eastbourne BN21 3UN, UK) V.105- 1949- Volume(issue)/page/year: 133,211,1977

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
RTECS	CZ9090000
HS Code	2935009090

Precursor 8
CAS#:704-22-3 3-(1,2,2-trichl... CAS#:700-60-7 Benzene,(1,2,2-... CAS#:4714-36-7 1-nitro-4-(1,2,... CAS#:721-24-4 3-Nitro Penta C...
CAS#:63630-17-1 4-(Trichlorethe... CAS#:710-72-5 3-pentachloroet... CAS#:63630-19-3 2-nitro-4-(1,2,... CAS#:63630-18-2 2-nitro-4-(1,2,...
DownStream 1
CAS#:60285-85-0 4-amino-6-(1,2,...

HS Code	2935009090
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Efficacy of an anthelmintic combination in sheep infected with Fasciola hepatica resistant to albendazole and clorsulon.

Exp. Parasitol. 136 , 59-62, (2014)

In the current study, we identified five sheep flocks with fasciolosis in the province of León (northwestern Spain) in order to determine the anthelmintic resistance status to three commonly used anth...

Intraspecific mitochondrial DNA variation of Fasciola hepatica eggs from sheep with different level of anthelmintic resistance.

Parasitol. Res. 113(7) , 2733-41, (2014)

In the current study, Fasciola hepatica strains of sheep with different degrees of resistance to anthelmintics were analyzed by sequencing the cytochrome C oxidase (COX1) and the NADH dehydrogenase (N...

Efficacy of an injectable combination anthelmintic (nitroxynil+clorsulon+ivermectin) against early immature Fasciola hepatica compared to triclabendazole combination flukicides given orally or topically to cattle.

Vet. Parasitol. 162(3-4) , 278-84, (2009)

The objective was to compare the efficacy against artificially induced 2- and 4-week old early immature triclabendazole-susceptible liver flukes (Fasciola hepatica) of an injectable combination of nit...

Clorsulon [Spanish]

UNII-EG1ZDO6LRD

EINECS 262-100-2

Clorsulonum [Latin]

4-amino-6-trichlorovinyl-1,3-benzenedisulfonamide

4-Amino-6-(trichlorovinyl)benzene-1,3-disulfonamide

Ivomec-F

4-amino-6-(trichloroethenyl)benzene-1,3-disulfonamide

MFCD00072006

Clorsulone [French]

Clorsulon

1,3-Benzenedisulfonamide, 4-amino-6-(1,2,2-trichloroethenyl)-

Curatrem

4-amino-6-trichloroethenyl-1,3-benzenedisulfonamide

4-Amino-6-(trichlorethenyl)-1,3-benzoldisulfonamid

MK-401

4-Amino-6-(trichlorovinyl)-1,3-benzenedisulfonamide

DC Chemicals Limited
China
Product Name: Clorsulon
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Zhejiang Hangyu API Co., Ltd
China
Product Name: Clorsulon
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 4-amino-6-(1,2,2-trichloroethenyl)benzene-1,3-disulfonamide
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Price: $79/10mM*1mLinDMSO

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Clorsulon

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