5-Hydroxymebendazole

Modify Date: 2024-01-02 17:59:19

5-Hydroxymebendazole structure	Common Name	5-Hydroxymebendazole
	CAS Number	60254-95-7	Molecular Weight	297.30900
	Density	1.401g/cm3	Boiling Point	438.82°C (rough estimate)
	Molecular Formula	C₁₆H₁₅N₃O₃	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A

Use of 5-Hydroxymebendazole

5-Hydroxymebendazole is the one metabolite of Benzimidazoles. Benzimidazoles are safe, broad-spectrum anthelmintic drugs and are widely used for prevention and treatment of parasitic infections in food-producing animals[1].

Name	Methyl {6-[hydroxy(phenyl)methyl]-1H-benzimidazol-2-yl}carbamate
Synonym	More Synonyms

Description	5-Hydroxymebendazole is the one metabolite of Benzimidazoles. Benzimidazoles are safe, broad-spectrum anthelmintic drugs and are widely used for prevention and treatment of parasitic infections in food-producing animals[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Hou XL, et al. Development and validation of an ultra high performance liquid chromatography tandem mass spectrometry method for simultaneous determination of sulfonamides, quinolones and benzimidazoles in bovine milk. J Chromatogr B Analyt Technol Biomed Life Sci. 2014;962:20‐29.

Density	1.401g/cm3
Boiling Point	438.82°C (rough estimate)
Molecular Formula	C₁₆H₁₅N₃O₃
Molecular Weight	297.30900
Exact Mass	297.11100
PSA	90.73000
LogP	2.83650
Index of Refraction	1.716

5-Hydroxymebendazole MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DD6498000

CHEMICAL NAME :: 2-Benzimidazolecarbamic acid, 5-(alpha-hydroxybenzyl)-, methyl ester

CAS REGISTRY NUMBER :: 60254-95-7

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C16-H15-N3-O3

MOLECULAR WEIGHT :: 297.34

WISWESSER LINE NOTATION :: T56 BM DNJ CMVO1 GYQR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 59200 ug/kg

SEX/DURATION :: female 8-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 59200 ug/kg

SEX/DURATION :: female 8-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Human Cells - not otherwise specified

DOSE/DURATION :: 2 mg/L

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 31,505,1976

RIDADR	NONH for all modes of transport
RTECS	DD6498000
HS Code	2933990090

Mebendazole

CAS#:31431-39-7

~87%

5-Hydroxymebendazole

CAS#:60254-95-7

Literature: Sharma; Ojha; Singh; Bhakuni; Srivastava; Gupta; Katiyar Indian Journal of Chemistry - Section B Organic Chemistry Including Medicinal Chemistry, 1989 , vol. 28, # 8 p. 702 - 704

Precursor 1
CAS#:31431-39-7 Mebendazole
DownStream 0

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Development and validation of an ultra high performance liquid chromatography tandem mass spectrometry method for simultaneous determination of sulfonamides, quinolones and benzimidazoles in bovine milk.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 962 , 20-9, (2014)

A simple, sensitive and reliable analytical method was developed for the simultaneous determination of 38 veterinary drugs (18 sulfonamides, 11 quinolones and 9 benzimidazoles) and 8 metabolites of be...

Efficacy of methyl 5(6)-(alpha-hydroxyphenylmethyl) benzimidazole-2-carbamate, a metabolite of mebendazole, against developing forms of experimental helminth parasites.

Indian J. Exp. Biol. 29(7) , 645-8, (1991)

Methyl 5(6)-(alpha-hydroxyphenylmethyl) benzimidazole-2- carbamate, a metabolite of mebendazole, was evaluated against metamorphic forms of Ancylostoma ceylanicum in hamsters, Nippostrongylus brasilie...

Alterations in metabolic activity of Cysticercus fasciolaris on some anthelmintic treatments.

Indian J. Exp. Biol. 30(4) , 320-3, (1992)

Effect of candidate compounds 81-470 i.e. methyl [5[4-(2-pyridinyl)-1-piperazinyl]carbonyl]-1H-benzimidazole-2-yl]- carbamate and 86-162 i.e. methyl-5(6)-(alpha-hydroxyphenyl methyl) benzimidazole-2-c...

5-Hydroxylaminopyridin-2-carbonsaeure

tupichilignan A

5-hydroxymebendazole

5-hydroxymatairesinol dimethyl ether

5-Hydroxylaminopicolinsaeure

DC Chemicals Limited
China
Product Name: 5-Hydroxymebendazole
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 5-hydroxymebendazole
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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