5-Hydroxymebendazole
5-Hydroxymebendazole structure
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Common Name | 5-Hydroxymebendazole | ||
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| CAS Number | 60254-95-7 | Molecular Weight | 297.30900 | |
| Density | 1.401g/cm3 | Boiling Point | 438.82°C (rough estimate) | |
| Molecular Formula | C16H15N3O3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
Use of 5-Hydroxymebendazole5-Hydroxymebendazole is the one metabolite of Benzimidazoles. Benzimidazoles are safe, broad-spectrum anthelmintic drugs and are widely used for prevention and treatment of parasitic infections in food-producing animals[1]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | Methyl {6-[hydroxy(phenyl)methyl]-1H-benzimidazol-2-yl}carbamate |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | 5-Hydroxymebendazole is the one metabolite of Benzimidazoles. Benzimidazoles are safe, broad-spectrum anthelmintic drugs and are widely used for prevention and treatment of parasitic infections in food-producing animals[1]. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.401g/cm3 |
|---|---|
| Boiling Point | 438.82°C (rough estimate) |
| Molecular Formula | C16H15N3O3 |
| Molecular Weight | 297.30900 |
| Exact Mass | 297.11100 |
| PSA | 90.73000 |
| LogP | 2.83650 |
| Index of Refraction | 1.716 |
| InChIKey | IIQKUGXEGMZCLE-UHFFFAOYSA-N |
| SMILES | COC(=O)Nc1nc2ccc(C(O)c3ccccc3)cc2[nH]1 |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| RIDADR | NONH for all modes of transport |
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| RTECS | DD6498000 |
| HS Code | 2933990090 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
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~87%
5-Hydroxymebendazole CAS#:60254-95-7 |
| Literature: Sharma; Ojha; Singh; Bhakuni; Srivastava; Gupta; Katiyar Indian Journal of Chemistry - Section B Organic Chemistry Including Medicinal Chemistry, 1989 , vol. 28, # 8 p. 702 - 704 |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 1 | |
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| DownStream 0 | |
This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Development and validation of an ultra high performance liquid chromatography tandem mass spectrometry method for simultaneous determination of sulfonamides, quinolones and benzimidazoles in bovine milk.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 962 , 20-9, (2014) A simple, sensitive and reliable analytical method was developed for the simultaneous determination of 38 veterinary drugs (18 sulfonamides, 11 quinolones and 9 benzimidazoles) and 8 metabolites of be... |
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Efficacy of methyl 5(6)-(alpha-hydroxyphenylmethyl) benzimidazole-2-carbamate, a metabolite of mebendazole, against developing forms of experimental helminth parasites.
Indian J. Exp. Biol. 29(7) , 645-8, (1991) Methyl 5(6)-(alpha-hydroxyphenylmethyl) benzimidazole-2- carbamate, a metabolite of mebendazole, was evaluated against metamorphic forms of Ancylostoma ceylanicum in hamsters, Nippostrongylus brasilie... |
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Alterations in metabolic activity of Cysticercus fasciolaris on some anthelmintic treatments.
Indian J. Exp. Biol. 30(4) , 320-3, (1992) Effect of candidate compounds 81-470 i.e. methyl [5[4-(2-pyridinyl)-1-piperazinyl]carbonyl]-1H-benzimidazole-2-yl]- carbamate and 86-162 i.e. methyl-5(6)-(alpha-hydroxyphenyl methyl) benzimidazole-2-c... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Inhibition of Cryptosporidium parvum CDPK1
Source: ChEMBL
Target: N/A
External Id: CHEMBL2061831
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Name: Drug level in human intestinal S9 fraction treated with 10 uM mebendazole 20.69 mins ...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3535600
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Name: Inhibition of Toxoplasma gondii CDPK1
Source: ChEMBL
Target: Calmodulin-domain protein kinase 1
External Id: CHEMBL2061832
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Name: Drug level in human liver S9 fraction treated with 10 uM mebendazole after 19.80 to 2...
Source: ChEMBL
Target: Liver
External Id: CHEMBL3532635
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Name: Drug level in human intestinal cytosol treated with 10 uM mebendazole after 20.74 min...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3532636
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Name: Drug level in human liver cytosol treated with 10 uM mebendazole after 20.80 mins by ...
Source: ChEMBL
Target: Liver cytosol
External Id: CHEMBL3532634
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 5-Hydroxylaminopyridin-2-carbonsaeure |
| tupichilignan A |
| 5-hydroxymebendazole |
| 5-hydroxymatairesinol dimethyl ether |
| 5-Hydroxylaminopicolinsaeure |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the molecular weight of Methyl {6-[hydroxy(phenyl)methyl]-1H-benzimidazol-2-yl}carbamate? |
| A: Molecular weight of Methyl {6-[hydroxy(phenyl)methyl]-1H-benzimidazol-2-yl}carbamate is 297.30900. |
| Q: What is the English name of Methyl {6-[hydroxy(phenyl)methyl]-1H-benzimidazol-2-yl}carbamate? |
| A: The English name of Methyl {6-[hydroxy(phenyl)methyl]-1H-benzimidazol-2-yl}carbamate is Methyl {6-[hydroxy(phenyl)methyl]-1H-benzimidazol-2-yl}carbamate. |
| Q: What is the SMILES notation of Methyl {6-[hydroxy(phenyl)methyl]-1H-benzimidazol-2-yl}carbamate? |
| A: SMILES notation of Methyl {6-[hydroxy(phenyl)methyl]-1H-benzimidazol-2-yl}carbamate is COC(=O)Nc1nc2ccc(C(O)c3ccccc3)cc2[nH]1. |
| Q: What are the uses of Methyl {6-[hydroxy(phenyl)methyl]-1H-benzimidazol-2-yl}carbamate? |
| A: Main uses of Methyl {6-[hydroxy(phenyl)methyl]-1H-benzimidazol-2-yl}carbamate: 5-Hydroxymebendazole is the one metabolite of Benzimidazoles. Benzimidazoles are safe, broad-spectrum anthelmintic drugs and are widely used for prevention and treatment of parasitic infections in food-producing animals[1]. |
| Q: What is the InChIKey of Methyl {6-[hydroxy(phenyl)methyl]-1H-benzimidazol-2-yl}carbamate? |
| A: InChIKey of Methyl {6-[hydroxy(phenyl)methyl]-1H-benzimidazol-2-yl}carbamate is IIQKUGXEGMZCLE-UHFFFAOYSA-N. |
| Q: What are the upstream materials of Methyl {6-[hydroxy(phenyl)methyl]-1H-benzimidazol-2-yl}carbamate? |
| A: Related upstream materials(CAS) of Methyl {6-[hydroxy(phenyl)methyl]-1H-benzimidazol-2-yl}carbamate: 31431-39-7. |
| Q: What is the LogP of Methyl {6-[hydroxy(phenyl)methyl]-1H-benzimidazol-2-yl}carbamate? |
| A: LogP of Methyl {6-[hydroxy(phenyl)methyl]-1H-benzimidazol-2-yl}carbamate is 2.83650. |
| Q: What is the polar surface area (PSA) of Methyl {6-[hydroxy(phenyl)methyl]-1H-benzimidazol-2-yl}carbamate? |
| A: Polar surface area (PSA) of Methyl {6-[hydroxy(phenyl)methyl]-1H-benzimidazol-2-yl}carbamate is 90.73000. |
| Q: What is the boiling point of Methyl {6-[hydroxy(phenyl)methyl]-1H-benzimidazol-2-yl}carbamate? |
| A: Boiling point of Methyl {6-[hydroxy(phenyl)methyl]-1H-benzimidazol-2-yl}carbamate is 438.82°C (rough estimate). |
| Q: What is the CAS number of Methyl {6-[hydroxy(phenyl)methyl]-1H-benzimidazol-2-yl}carbamate? |
| A: CAS number of Methyl {6-[hydroxy(phenyl)methyl]-1H-benzimidazol-2-yl}carbamate is 60254-95-7. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |