Leucovorin Calcium Pentahydrate

Modify Date: 2024-01-03 10:17:45

Leucovorin Calcium Pentahydrate Structure
Leucovorin Calcium Pentahydrate structure
Common Name Leucovorin Calcium Pentahydrate
CAS Number 6035-45-6 Molecular Weight 601.58
Density N/A Boiling Point N/A
Molecular Formula C20H31CaN7O12 Melting Point 240-250ºC
MSDS N/A Flash Point N/A

 Use of Leucovorin Calcium Pentahydrate


Folinic Acid is a reduced folic acid, which is used in combination with other chemotherapy drugs.Target: Folate analogApproved: 2008Folinic acid (calcium salt pentahydrate) is the calcium salt form of folinic acid, which is one of the forms of folate found naturally in foods. Folate deficiency is believed to be the most common vitamin deficiency in the world due to food processing, food selection, and intestinal disorders. Folinic acid in the body can be converted into any of the other active forms of folate.Treatment with folinic acid calcium salt pentahydrate (CF) could cause improved development in the heart and vessels in MTX-treated embryos, which proved that MTX induced the malformations by inhibiting DHFR. The transcript levels of genes such as hand2, mef2a, mef2c, and flk-1 were reduced in MTX-treated embryos. Compared with the MTX-treated group, the transcript levels of hand2, mef2a, mef2c, and flk-1 were increased in the MTX + dhfr-gfp mRNA-injected group and in the MTX + CF group [1]. Folinic acid may also be useful in the treatment of acute methotrexate overdose. Different dosing protocols are used, but folinic acid should be re-dosed until the methotrexate level is less than 5 x 10-8 M [2].

 Names

Name Calcium folinatc
Synonym More Synonyms

 Leucovorin Calcium Pentahydrate Biological Activity

Description Folinic Acid is a reduced folic acid, which is used in combination with other chemotherapy drugs.Target: Folate analogApproved: 2008Folinic acid (calcium salt pentahydrate) is the calcium salt form of folinic acid, which is one of the forms of folate found naturally in foods. Folate deficiency is believed to be the most common vitamin deficiency in the world due to food processing, food selection, and intestinal disorders. Folinic acid in the body can be converted into any of the other active forms of folate.Treatment with folinic acid calcium salt pentahydrate (CF) could cause improved development in the heart and vessels in MTX-treated embryos, which proved that MTX induced the malformations by inhibiting DHFR. The transcript levels of genes such as hand2, mef2a, mef2c, and flk-1 were reduced in MTX-treated embryos. Compared with the MTX-treated group, the transcript levels of hand2, mef2a, mef2c, and flk-1 were increased in the MTX + dhfr-gfp mRNA-injected group and in the MTX + CF group [1]. Folinic acid may also be useful in the treatment of acute methotrexate overdose. Different dosing protocols are used, but folinic acid should be re-dosed until the methotrexate level is less than 5 x 10-8 M [2].
Related Catalog
References

[1]. Sun, S., et al., Effects of methotrexate on the developments of heart and vessel in zebrafish. Acta Biochim Biophys Sin (Shanghai), 2009. 41(1): p. 86-96.

[2]. www.cancercare.on.ca/pdfdrugs/leucovo.pdf

 Chemical & Physical Properties

Melting Point 240-250ºC
Molecular Formula C20H31CaN7O12
Molecular Weight 601.58
PSA 427.76000
Storage condition -20℃

 Safety Information

Hazard Codes Xn: Harmful;
Risk Phrases 36/37/38-42/43
Safety Phrases 26-36
WGK Germany 3
HS Code 2942000000

 Precursor & DownStream

Precursor  0

DownStream  1

 Customs

HS Code 2942000000

 Synonyms

Folaren
Foliben
5-formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid calcium salt
FOLINIC ACID CALCIUM CELL CULTURE TESTED
Folinic acid calcium salt
Folidan
Leucovorin 30(R)
CALCIUM FOLINATE(FOLINIC ACID)(RG)
Calcium 2-amino-6-[(4-{[(1S)-1-carboxy-3-carboxylatopropyl]carbamoyl}phenyl)(methyl)amino]-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridine 2-amino-6-[{4-[(1-carboxy-3-carboxylatopropyl)carbamoyl]phenyl}(methyl)amino]-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridine (1:1:1)
(6S)-calcium folinate
Leucovorin Calcium
Leucovorin calcium pentahydrate
FOLINIC ACID(SEE CALCIUM FOLINATE)
Folinic acid (calcium salt pentahydrate)
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