6-Iodoamiloride

Modify Date: 2024-01-12 15:24:57

6-Iodoamiloride Structure
6-Iodoamiloride structure
Common Name 6-Iodoamiloride
CAS Number 60398-23-4 Molecular Weight 321.08
Density 2.74g/cm3 Boiling Point 657.5ºC at 760 mmHg
Molecular Formula C6H8IN7O Melting Point N/A
MSDS N/A Flash Point 351.4ºC

 Use of 6-Iodoamiloride


6-Iodoamiloride is a potent acid-sensing ion channel 1 (ASIC1) inhibitor with an IC50 of 88 nM. 6-Iodoamiloride inhibits ASIC3-mediated currents from rat dorsal root ganglion neurons with an IC50 of 230 nM[1].

 Names

Name 3,5-diamino-N-(diaminomethylidene)-6-iodopyrazine-2-carboxamide
Synonym More Synonyms

 6-Iodoamiloride Biological Activity

Description 6-Iodoamiloride is a potent acid-sensing ion channel 1 (ASIC1) inhibitor with an IC50 of 88 nM. 6-Iodoamiloride inhibits ASIC3-mediated currents from rat dorsal root ganglion neurons with an IC50 of 230 nM[1].
Related Catalog
Target

IC50: 88 nM (ASIC1)[1]

References

[1]. Rocio K Finol-Urdaneta, et al. Automated Patch Clamp Screening of Amiloride and 5- N, N-Hexamethyleneamiloride Analogs Identifies 6-Iodoamiloride as a Potent Acid-Sensing Ion Channel Inhibitor. Mol Pharm. 2023 Jul 3;20(7):3367-3379.  

 Chemical & Physical Properties

Density 2.74g/cm3
Boiling Point 657.5ºC at 760 mmHg
Molecular Formula C6H8IN7O
Molecular Weight 321.08
Flash Point 351.4ºC
Exact Mass 320.98400
PSA 160.28000
LogP 1.40610
Index of Refraction 1.988

 Safety Information

HS Code 2934999090

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

3,5-diamino-6-iodo-pyrazine-2-carboxylic acid carbamimidoylamide
N-Amidino-3,5-diamino-6-iodo-2-pyrazinecarboxamide
6-Iodoamiloride