TY-51469

Modify Date: 2024-02-02 15:38:58

TY-51469 structure	Common Name	TY-51469
	CAS Number	603987-59-3	Molecular Weight	526.60
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₁₅FN₂O₆S₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of TY-51469

TY-51469 is a chymase inhibitor with IC50s for simian and human chymases of 0.4 and 7.0 nM, respectively.

Name	TY-51469

Description	TY-51469 is a chymase inhibitor with IC50s for simian and human chymases of 0.4 and 7.0 nM, respectively.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
Target	IC50: 0.4 nM (Simian chymase), 0.7 nM (Human chymase)[1]
In Vivo	TY-51469 shows 100% stability in rat plasma at 40°C for as long as 1 hour[1]. TY-51469 suppresses the accumulation of neutrophils in the lung and reduces silica-induced pulmonary fibrosis in mice[2].
Animal Admin	Rats[1] The 2-week intravenous repeated-dose toxicity study of TY-51469 was conducted in male Sprague-Dawley rats at daily doses of 0 (control), 20, and 60 mg/kg[1]. Mice[1] the chymase inhibitor TY-51469 was administered daily at a dose of 0.1 or 1.0 mg/kg/day for 21 days using an osmotic pump to male 8-week-old ICR mice. The osmotic pump released the drug solution continuously at a rate of 0.3 µL/h for 21 days[2].
References	[1]. Takato H, et al. The specific chymase inhibitor TY-51469 suppresses the accumulation of neutrophils in the lung and reduces silica-induced pulmonary fibrosis in mice. Expert Opinion on Therapeutic Targets Volume 15, 2011 - Issue 4.

Molecular Formula	C₂₀H₁₅FN₂O₆S₄
Molecular Weight	526.60

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: TY-51469
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

Get all suppliers and price by the below link:

TY-51469 suppliers