N-acetyl-nor-muramyl-L-alanyl-D-isoglutamine

Modify Date: 2024-01-03 11:33:06

N-acetyl-nor-muramyl-L-alanyl-D-isoglutamine Structure
N-acetyl-nor-muramyl-L-alanyl-D-isoglutamine structure
Common Name N-acetyl-nor-muramyl-L-alanyl-D-isoglutamine
CAS Number 61136-12-7 Molecular Weight 478.45100
Density N/A Boiling Point N/A
Molecular Formula C18H30N4O11 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of N-acetyl-nor-muramyl-L-alanyl-D-isoglutamine


Almurtide (nor-MDP), a muramyl dipeptide derivative with anti-inflammatory and anti-tumor activity. Almurtide also shows protective effects against intraperitoneal Pseudomonas aeruginosa infection or intravenously Candida albicans infection in mice. Almurtide also inhibits the carcinogenic Friend leukemia virus[1][2][3].

 Names

Name (4R)-4-[[(2S)-2-[[2-[(2R,3R,4R,5R)-2-acetamido-4,5,6-trihydroxy-1-oxohexan-3-yl]oxyacetyl]amino]propanoyl]amino]-5-amino-5-oxopentanoic acid
Synonym More Synonyms

  Biological Activity

Description Almurtide (nor-MDP), a muramyl dipeptide derivative with anti-inflammatory and anti-tumor activity. Almurtide also shows protective effects against intraperitoneal Pseudomonas aeruginosa infection or intravenously Candida albicans infection in mice. Almurtide also inhibits the carcinogenic Friend leukemia virus[1][2][3].
Related Catalog
In Vivo Almurtide (80 mg/kg; 每天 1 次, 连续 4 天; 腹腔注射,静脉注射或皮下注射) 非特异性刺激巨噬细胞,对单核增生李斯特菌有抗感染活性。同时,它缺少口服活性,和庆大霉素 (HY-A0276A) 之间存在协同作用[2]。 Almurtide (100 μg/mouse; 皮下注射; 2-3 个月 1 次, 共 2 次) 防止低剂量 Friend 白血病病毒引起的 SJL/J 小鼠的红白血病,延缓 RIII/Imr 小鼠自发乳腺肿瘤的发生[3]。
References

[1]. Díaz-Eufracio BI, et al. Exploring the chemical space of peptides for drug discovery: a focus on linear and cyclic penta-peptides. Mol Divers. 2018 May;22(2):259-267.  

[2]. Fraser-Smith E B, et al. Protective effect of muramyl dipeptide analogs against infections of Pseudomonas aeruginosa or Candida albicans in mice. Infection and immunity, 1981, 34(3): 676-683.

[3]. Acevedo H F, et al. Prevention of oncogenic viral infections in mice with CGP 11637, a synthetic muramyl dipeptide analog[J]. Antimicrobial agents and chemotherapy, 1985, 28(5): 589-596.

 Chemical & Physical Properties

Molecular Formula C18H30N4O11
Molecular Weight 478.45100
Exact Mass 478.19100
PSA 266.14000

 Synonyms

N-Acetyl-nor-muramyl-L-alanyl-D-isoglutamine
UNII-1DCO35D4OR
Nor-MDP