N-acetyl-nor-muramyl-L-alanyl-D-isoglutamine

Modify Date: 2024-01-03 11:33:06

N-acetyl-nor-muramyl-L-alanyl-D-isoglutamine structure	Common Name	N-acetyl-nor-muramyl-L-alanyl-D-isoglutamine
	CAS Number	61136-12-7	Molecular Weight	478.45100
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈H₃₀N₄O₁₁	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of N-acetyl-nor-muramyl-L-alanyl-D-isoglutamine

Almurtide (nor-MDP), a muramyl dipeptide derivative with anti-inflammatory and anti-tumor activity. Almurtide also shows protective effects against intraperitoneal Pseudomonas aeruginosa infection or intravenously Candida albicans infection in mice. Almurtide also inhibits the carcinogenic Friend leukemia virus[1][2][3].

Name	(4R)-4-[[(2S)-2-[[2-[(2R,3R,4R,5R)-2-acetamido-4,5,6-trihydroxy-1-oxohexan-3-yl]oxyacetyl]amino]propanoyl]amino]-5-amino-5-oxopentanoic acid
Synonym	More Synonyms

Description	Almurtide (nor-MDP), a muramyl dipeptide derivative with anti-inflammatory and anti-tumor activity. Almurtide also shows protective effects against intraperitoneal Pseudomonas aeruginosa infection or intravenously Candida albicans infection in mice. Almurtide also inhibits the carcinogenic Friend leukemia virus[1][2][3].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vivo	Almurtide (80 mg/kg; 每天 1 次, 连续 4 天; 腹腔注射，静脉注射或皮下注射) 非特异性刺激巨噬细胞，对单核增生李斯特菌有抗感染活性。同时，它缺少口服活性，和庆大霉素 (HY-A0276A) 之间存在协同作用[2]。 Almurtide (100 μg/mouse; 皮下注射; 2-3 个月 1 次, 共 2 次) 防止低剂量 Friend 白血病病毒引起的 SJL/J 小鼠的红白血病，延缓 RIII/Imr 小鼠自发乳腺肿瘤的发生[3]。
References	[1]. Díaz-Eufracio BI, et al. Exploring the chemical space of peptides for drug discovery: a focus on linear and cyclic penta-peptides. Mol Divers. 2018 May;22(2):259-267. [2]. Fraser-Smith E B, et al. Protective effect of muramyl dipeptide analogs against infections of Pseudomonas aeruginosa or Candida albicans in mice. Infection and immunity, 1981, 34(3): 676-683. [3]. Acevedo H F, et al. Prevention of oncogenic viral infections in mice with CGP 11637, a synthetic muramyl dipeptide analog[J]. Antimicrobial agents and chemotherapy, 1985, 28(5): 589-596.

Molecular Formula	C₁₈H₃₀N₄O₁₁
Molecular Weight	478.45100
Exact Mass	478.19100
PSA	266.14000

N-Acetyl-nor-muramyl-L-alanyl-D-isoglutamine

UNII-1DCO35D4OR

Nor-MDP

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: N-acetyl-nor-muramyl-L-alanyl-D-isoglutamine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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