O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine hydrochloride

Modify Date: 2025-09-18 22:17:48

O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine hydrochloride structure	Common Name	O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine hydrochloride
	CAS Number	6138-47-2	Molecular Weight	687.43400
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₅H₁₃ClI₃NO₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine hydrochloride

Liothyronine hydrochloride is an active form of thyroid hormone. Liothyronine hydrochloride is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively[1][2][3].

Name	(2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid,hydrochloride
Synonym	More Synonyms

Description	Liothyronine hydrochloride is an active form of thyroid hormone. Liothyronine hydrochloride is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively[1][2][3].
Related Catalog	Research Areas >> Cancer Research Areas >> Endocrinology Signaling Pathways >> Others >> Thyroid Hormone Receptor
Target	Human Endogenous Metabolite
In Vitro	Liothyronine (T3, 100 nM) hydrochloride stimulates the proliferation of hepatocarcinema cells in which TRβ1 is overexpressed[1]. Liothyronine hydrochloride binds to human β1 thyroid hormone receptor (hTRβ1), and changes its conformation. Liothyronine hydrochloride promotes growth, induces differentiation and regualtes metabolic effects[2].
References	[1]. Lin KH, et al. Stimulation of proliferation by 3,3',5-triiodo-L-thyronine in poorly differentiated human hepatocarcinoma cells overexpressing beta 1 thyroid hormone receptor. Cancer Lett. 1994 Oct 14;85(2):189-94. [2]. Bhat MK, et al. Conformational changes of human beta 1 thyroid hormone receptor induced by binding of 3,3',5-triiodo-L-thyronine. Biochem Biophys Res Commun. 1993 Aug 31;195(1):385-92. [3]. Hiroaki Shiohara, et al. Discovery of novel indane derivatives as liver-selective thyroid hormone receptor β (TRβ) agonists for the treatment of dyslipidemia. Bioorg Med Chem. 2012 Jun 1;20(11):3622-34.

Molecular Formula	C₁₅H₁₃ClI₃NO₄
Molecular Weight	687.43400
Exact Mass	686.76700
PSA	92.78000
LogP	5.45500
InChIKey	HFEMPWKWYHWPQX-YDALLXLXSA-N
SMILES	Cl.NC(Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(=O)O

Liothyronine hydrochloride

trionine

Liothyronine HCl

Thyrotradin (TN)

EINECS 228-120-0

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