2'-NH2-ATP

Modify Date: 2024-01-10 19:18:31

2'-NH2-ATP Structure
2'-NH2-ATP structure
Common Name 2'-NH2-ATP
CAS Number 61468-88-0 Molecular Weight 506.20
Density N/A Boiling Point N/A
Molecular Formula C10H17N6O12P3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 2'-NH2-ATP


2'-NH2-ATP (2'-Amino-2'-deoxyadenosine-5'-triphosphate), an adenosine derivative, is a weak competitive inhibitor of ATP, with a Ki of 2.3 mM. 2'-NH2-ATP can be used in nucleic acid labeling[1][2][3].

 Names

Name 2'-NH2-ATP

 2'-NH2-ATP Biological Activity

Description 2'-NH2-ATP (2'-Amino-2'-deoxyadenosine-5'-triphosphate), an adenosine derivative, is a weak competitive inhibitor of ATP, with a Ki of 2.3 mM. 2'-NH2-ATP can be used in nucleic acid labeling[1][2][3].
Related Catalog
In Vitro 2'-NH2-ATP (2 mM) did not replace ATP as a substrate for NH3-dependent cytidine 5'-triphosphate (CTP) formation catalyzed by CTP synthase[2].
References

[1]. Armstrong VW, et, al. Interaction of substrate analogues with Escherichia coli DNA-dependent RNA polymerase. Eur J Biochem. 1976 Nov 1;70(1):33-8.

[2]. Faylene A. L. KINETIC STUDIES ON WILD-TYPE AND MUTANT ESCHERICHIA COLICYTIDINE 5'-TRIPHOSPHATE SYNTHASES AND INHIBITOR DEVELOPMENT. Dalhousie University Halifax, Nova Scotia. 2008 Jul.

[3]. Aström H, et, al. Acidity of secondary hydroxyls in ATP and adenosine analogues and the question of a 2',3'-hydrogen bond in ribonucleosides. J Am Chem Soc. 2004 Nov 17;126(45):14710-1.

 Chemical & Physical Properties

Molecular Formula C10H17N6O12P3
Molecular Weight 506.20
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